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首页> 外文期刊>Journal of Developmental and Physical Disabilities >Variables Associated with Increased Tic Severity in 5,500 Participants with Tourette Syndrome
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Variables Associated with Increased Tic Severity in 5,500 Participants with Tourette Syndrome

机译：与5,500名抽动秽语综合征参与者的抽动严重度增加相关的变量

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摘要

Objective: Tourette syndrome (TS) is a common developmental disorder with childhood onset. This study utilizes the TIC consortium data to develop models of variables associated with increased severity of tics in people with TS. The TIC database comprised 5,500 people with TS. Method: This study included the 5,450 participants with clinician reported severity of tics (mild, moderate, or severe). We developed 3 models of tic severity. Results: Model 1 comprised age of diagnosis and total number of comorbidities and correctly classified 71% of mild–moderate cases, 46% of severe, and 68% of the total group. Model 2 comprised 7 of 21 comorbid conditions and classified 78% of mild–moderate cases, 53% of severe cases, and 74% of the total population. Model 3 comprised 6 comorbid conditions and correctly classified 75% of mild–moderate cases, 57% of severe cases, and 72% of the total cohort. We found the attention-deficit hyperactivity disorder was not associated with tic severity but obsessive compulsive disorder was an important variable associated with tic severity. Conclusion: This large dataset provides 3 models of variables associated with increased tic severity at the time of diagnosis. Further research is needed to identify factors associated with longitudinal changes in tic severity. This should include factors that are associated with both increased and decreased severity.
机译：目的：Tourette综合征（TS）是一种常见的发育障碍，伴有儿童期发作。这项研究利用TIC联盟数据来开发与TS患者抽动严重程度相关的变量模型。 TIC数据库包含5500名TS患者。方法：本研究纳入了5,450名临床医师报告的抽搐严重程度（轻度，中度或重度）的参与者。我们开发了3种抽动严重程度模型。结果：模型1由诊断年龄和合并症总数组成，正确分类了71％的轻度-中度病例，46％的重度病例和68％的总群。模型2包含21种合并症中的7种，并将78％的轻度-中度病例，53％的严重病例和74％的总人群分类。模型3包含6种合并症，对75％的轻度-中度病例，57％的严重病例和72％的总人群进行了正确分类。我们发现注意缺陷多动障碍与抽动严重程度无关，而强迫症是与抽动严重程度有关的重要变量。结论：这个大型数据集提供了3种与诊断时抽动轻度加重相关的变量模型。需要进一步的研究来确定与抽搐严重程度的纵向变化相关的因素。这应包括与严重性增加和降低相关的因素。

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