• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Developmental and Physical Disabilities >Plasma Kynurenine Levels in Autistic Disorder
【24h】

Plasma Kynurenine Levels in Autistic Disorder

机译：自闭症的血浆Kynurenine水平

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Serotonin and its precursor tryptophan have long been implicated in the pathophysiology of autistic disorder (autism). Recent genetic evidence implicates involvement of a gene encoding tryptophan 2,3-dioxygenase, a rate-limiting enzyme in tryptophan's major metabolic pathway, the kynurenine pathway, in autism. To test activity of the kynurenine pathway in autism, plasma kynurenine levels were measured in 30 drug-free autistic children (mean age (SD)=6 years 0 months (2 years 9 months)) and 29 age-, race- and gender-matched healthy comparison subjects (mean age (SD)=6 years 5 months (2 years 6 months)) using high-performance liquid chromatography. No difference was found in plasma kynurenine levels between the study groups. In the autistic children, plasma kynurenine levels did not correlate with autistic behaviors or IQ. These results do not support a role for abnormal global function of the kynurenine pathway; however, the status of this pathway in the brain remains unknown.
机译：血清素及其前体色氨酸长期以来一直与自闭症（自闭症）的病理生理有关。最近的遗传证据表明，自闭症中色氨酸2,3-双加氧酶（一种限速酶）的编码基因参与色氨酸的主要代谢途径，犬尿氨酸途径。为了测试犬尿氨酸途径在自闭症中的活性，在30名无毒品自闭症儿童（平均年龄（SD）= 6岁0个月（2年9个月））和29位年龄，种族和性别的儿童中测量了血浆犬尿氨酸水平匹配的健康对照受试者（平均年龄（SD）= 6岁5个月（2岁6个月））使用高效液相色谱法。研究组之间血浆犬尿氨酸水平没有差异。在自闭症儿童中，血浆犬尿氨酸水平与自闭症行为或智商无关。这些结果不支持犬尿氨酸途径的总体功能异常；然而，该途径在大脑中的状态仍然未知。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号