Proteins were studied in nasal secretions obtained from Marine Corps trainees infected with wild adenovirus type 7 both during the acute phase of illness and after recovery. Illness was associated with a marked increase in the concentration of serum proteins in the secretions, and during inflammation there was no apparent barrier to the passage of large molecules (molecular weight 775,000) from the serum into the respiratory passages. At the time of virus isolation, trainees requiring hospitalization had less immunoglobulin A (IgA) in their secretions even though they had greater quantities of immunoglobin G (P < 0.05) and albumin than trainees followed in the field, whose secretions were also tested at the time of virus isolation. Base-line IgA and protein concentrations were lower (P < 0.05) in hospitalized trainees than in trainees followed prospectively in the field. The results suggest a nonspecific protective function for secretion protein, although we have not excluded the possibility that field study trainees were protected by specific neutralizing antibody present in the nasal secretion.
展开▼
机译：在患有野生腺病毒型7期间的野生腺病毒学员在疾病的急性阶段和恢复后，研究了蛋白质。疾病与分泌物中血清蛋白浓度的显着增加有关，并且在炎症期间对大分子（分子量775,000）从血清进入呼吸道通道的情况下没有明显的屏障。在病毒隔离时，即使它们具有更大数量的免疫球蛋白G（ P <0.05）和白蛋白，其特征在于病毒分泌物，其分泌物在其分泌中具有较少的免疫球蛋白A（IgA）。在病毒分离时还测试了谁的分泌物。在住院的学员中，基线IgA和蛋白质浓度低于住院学员，而不是在现场前瞻性的学员。结果表明了分泌蛋白的非特异性保护功能，尽管我们没有排除现场研究学员的可能性受到鼻分泌中存在的特异性中和抗体的保护。
展开▼
