首页> 外文期刊>Infection and immunity >Immunosuppression by hydroxystilbamidine isethionate, a lysosome-stabilizing, anti-proteolytic, antifungal drug.
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Immunosuppression by hydroxystilbamidine isethionate, a lysosome-stabilizing, anti-proteolytic, antifungal drug.

机译:羟基氨基氨基氨基甲烷的免疫抑制,溶酶体稳定,抗蛋白水解,抗真菌药物。

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摘要

Hydroxystilbamidine (HSB) is a potent suppressor of the plaque-forming cell response of mice injected with heterologous erythrocytes. HSB, given in varying doses and injection schedules, suppressed both the primary and secondary immune responses to bovine serum albumin. Apparently the effect is not simply a toxic effect on spleen cells, because there was no appreciable difference in cell numbers between control and HSB-treated mice. The effect of HSB was most apparent in the early phase of the immune respone.
机译:羟基氨基氨基(HSB)是注射异源红细胞的小鼠的斑块形成细胞响应的有效抑制剂。在不同剂量和注射时间表中给出的HSB,抑制了对牛血清白蛋白的主要和二次免疫应答。显然,效果不仅仅是对脾细胞的毒性作用,因为对照和HSB处理的小鼠之间没有明显的细胞数差异。 HSB在免疫应激的早期阶段最明显的影响。

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