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首页> 外文期刊>Infection and immunity >Relationship between delayed hypersensitivity response and acquired cell-mediated immunity in C57BL/6J mice infected with Leishmania donovani.
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Relationship between delayed hypersensitivity response and acquired cell-mediated immunity in C57BL/6J mice infected with Leishmania donovani.

机译：用Leishmania donovani感染的C57BL / 6J小鼠延迟超敏反应与获得的细胞介导免疫的关系。

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摘要

The relationship between the development of acquired cell-mediated immunity and the concomitant level of specific delayed hypersensitivity (DH) in C57BL/6J mice infected with the intracellular protozoan parasite Leishmania donovani was studied. It was determined that the intradermal injection of Leishmania antigen (heat- or phenol-killed flagellated forms of L. donovani) could elicit a DH response as early as day 10 and as late as day 120 postinfection in mice infected by the intravenous route. Dose-response studies showed that there is an inverse relationship between the size of the infecting dose of parasites and the magnitude of the DH response. Thus, increasing the degree of infection depressed the DH response. This depression, however, could be abrogated by treatment of mice with cyclophosphamide (201 mg/kg) before intradermal injection of antigen.
机译：研究了在C57BL / 6J小鼠中获得了蜂窝介导的免疫和特异性延迟超敏反应（DH）的伴随水平之间的关系。研究了与细胞内原生动物寄生虫Leishmania donovani的C57BL / 6J小鼠。据确定，皮内注射LeishMania抗原（Laivovani的热 - 或酚醛杀死的鞭打形式）可以尽早引发DH响应，并且随着静脉内途径感染的小鼠的120日，第120天晚期晚期。剂量 - 响应研究表明，感染剂量的寄生剂的大小与DH反应的大小之间存在反比关系。因此，增加了抑制了DH响应的感染程度。然而，这种抑郁症可以通过在皮内注射抗原的皮内注射抗原之前用环磷酰胺（201mg / kg）而废除。

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