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首页> 外文期刊>Infection and immunity >Relationship between the intestinal permeability to macromolecules and invasion of septicemia-inducing Escherichia coli in neonatal piglets.
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Relationship between the intestinal permeability to macromolecules and invasion of septicemia-inducing Escherichia coli in neonatal piglets.

机译：新生仔猪肠道渗透与败血症诱导大肠杆菌侵袭的关系。

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摘要

The influence of age and diet on the invasion of septicemia-inducing Escherichia coli and the endocytotic activity of the small intestinal epithelium were examined in colostrum-deprived conventional and gnotobiotic piglets orally infected with E. coli 078. The piglets infected at birth and the animals fed glucose-amino acids solution and infected at 3 days after birth soon suffered from septicemia caused by the invasion of E. coli 378. The piglets fed artifical milk and infected at 3 days after birth, however, showed resistance to the invasion of E. coli in the absence of passively acquired serum gamma globulin. The endocytotic activity of the small intestinal epithelium was more intense in the former than in the latter piglets. Some of the ileal epithelial cells of the piglets infected at birth contained organisms, although these cells were morphologically intact and showed intense endocytosis. The present results suggest that the intestinal permeability to macromolecules, which depends on the endocytotic activity of the small intestinal epithelium, might predispose neonatal piglets to colisepticemia.
机译：在初乳剥夺的常规和侏儒仔猪口服脱贫的常规和侏儒仔猪中检查了年龄和饮食对败血症诱导的大肠杆菌和小肠上皮的内核活性的影响。感染大肠杆菌078的侏儒仔猪喂养葡萄糖 - 氨基酸溶液并在出生后3天感染很快受到由大肠杆菌378侵袭引起的败血症。然而，饲喂人工乳和出生后3天感染的仔猪表现出对E的侵袭的抗性。在没有被动获得的血清γ球蛋白的情况下的大肠杆菌。小肠上皮的内吞活性在前者比后一仔猪更强烈。仔猪感染的仔猪的一些髂骨上皮细胞含有生物体，尽管这些细胞形态完整并显示出强烈的内吞作用。本结果表明，肠道渗透率取决于小肠上皮的内核活性，可能会使新生儿仔猪倾向于大肠杆菌癌。

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