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首页> 外文期刊>Journal of environmental science and health >Macrophage activity and histopathology of the lymphohematopoietic organs in male Wistar rats orally exposed to single or mixed pesticides
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Macrophage activity and histopathology of the lymphohematopoietic organs in male Wistar rats orally exposed to single or mixed pesticides

机译：口服单一或混合农药的雄性Wistar大鼠的巨噬细胞活性和淋巴造血器官的组织病理学

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摘要

The noxious effects of low or effective dose exposure to single or mixed pesticides on macrophage activity and the lymphohematopoietic organs were investigated. Male Wistar rats were orally exposed to dichlorvos, dicofol, endosulfan, dieldrin and permethrin, either as single or combined mixtures during a 28-day study containing eight groups: one group received a semipurified diet (non-treated); two groups received a semipurified diet containing low dose mixture (dieldrin 0.025 mg/kg, endosulfan, 0.6 mg/kg, dicofol 0.22 mg/kg, dichlorvos 0.23 mg/kg, permethrin 5 mg/kg) or an effective dose mixture (dichlorvos 2.3 mg/kg, dicofol 2.5 mg/kg, endosulfan 2.9 mg/kg, dieldrin 0.05 mg/kg and permethrin 25.0 mg/kg), respectively; the other five groups received a semipurified diet containing each single pesticide in effective doses. At sacrifice, the thymus, spleen, mesenteric lymph nodes, Payer's patches and bone marrow were removed for histological analysis. Peritoneal macrophages were obtained to determine the phagocytosis and spreading indexes and tumoral necrosis factor alpha (TNF-α), nitric oxide (NO) and H_2O_2 production. Exposure to pesticide mixtures did not alter the percentage of macrophage phagocytosis and spreading, TNF-α production or the NO and H_2O_2 release when compared to the non-treated group. Neither was there any apparent evidence that a pesticide mixture at low or effective doses altered the histological structure of the lymphohematopoietic organs. The findings indicate that short-term treatment with pesticide mixtures did not induce an apparent immunotoxic effect in male Wistar rats.
机译：研究了低剂量或有效剂量单一或混合农药对巨噬细胞活性和淋巴造血器官的有害影响。在28天的研究中，雄性Wistar大鼠经口含敌敌畏，三氯杀螨醇，硫丹，狄氏剂和苄氯菊酯，以单一混合物或混合混合物的形式口服，分为八组：一组接受半纯化饮食（未经治疗）；另一组接受半纯化饮食。两组接受半纯化饮食，其中包含低剂量混合物（狄氏剂0.025 mg / kg，硫丹，0.6 mg / kg，三氯杀螨醇0.22 mg / kg，敌敌畏2,3 mg / kg，氯菊酯5 mg / kg）或有效剂量的混合物（敌敌畏2.3毫克/千克，三氯杀螨醇2.5毫克/千克，硫丹2.9毫克/千克，狄氏剂0.05毫克/千克和苄氯菊酯25.0毫克/千克）;其他五组接受半纯化饮食，其中包含有效剂量的每种单一农药。处死时，去除胸腺，脾脏，肠系膜淋巴结，Payer斑块和骨髓，以进行组织学分析。获得腹膜巨噬细胞以确定吞噬作用和扩散指数以及肿瘤坏死因子α（TNF-α），一氧化氮（NO）和H_2O_2的产生。与未处理组相比，接触农药混合物不会改变巨噬细胞吞噬作用和扩散，TNF-α产生或NO和H_2O_2释放的百分比。没有任何明显的证据表明低剂量或有效剂量的农药混合物会改变淋巴造血器官的组织学结构。这些发现表明，用农药混合物进行短期治疗不会对雄性Wistar大鼠产生明显的免疫毒性作用。

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