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首页> 外文期刊>Journal of environmental science and health >Design and development of novel insect growth regulators:Synthesis, characterization and effect of benzoyl thymyl thioureas and ureas on total haemocyte count of Dysdercus koenigii
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Design and development of novel insect growth regulators:Synthesis, characterization and effect of benzoyl thymyl thioureas and ureas on total haemocyte count of Dysdercus koenigii

机译：新型昆虫生长调节剂的设计与开发：苯甲酰胸腺嘧啶硫脲和尿素的合成，表征及对拟南芥总血细胞计数的影响

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摘要

Insect-growth regulators (IGRs) have been receiving foremost attention as potential means of selective insect control. Benzoyl phenyl urea (BPU) is a well-known IGR having chitin synthesis inhibitor activity. Mimics of BPU have been synthesized by suitable derivatization of a naturally occurring monoterpenoid, thymol (2-isopropyl-5-methyl phenol) to form a = series of substituted benzoyl thymyl thioureas (BTTUs) [IVa-f] and benzoyl thymyl ureas (BTUs) [Va-f]. The synthesized compounds have been characterized by 'H and 13C NMR, LC-MS and elemental analysis. These derivatives have been screened for their effect on total haemocyte count of Dysdercus koenigii. It has been observed that the introduction of substituted benzoyl thiourea and urea linkage into a thymol ring via an amino group results in higher activity than the parent compound thymol and a comparable pattern of results with the standard insect-growth regulators, Penfluron. Urea [Va-f] compounds exhibited greater effect on Total Haemocyte Count (THC) than thiourea [IVa-f]. Fluoro substitution enhanced the effect on THC more than chloro substituted compounds, while ortho-substitution resulted in a better effect than para-substitution. The results described in this paper are promising and provide new array of synthetic chemicals that may be utilized as insect growth regulators.
机译：作为选择性昆虫控制的潜在手段，昆虫生长调节剂（IGR）受到了最广泛的关注。苯甲酰基苯基脲（BPU）是具有甲壳质合成抑制剂活性的众所周知的IGR。 BPU的模拟物是通过自然衍生的单萜类百里酚（2-异丙基-5-甲基苯酚）的适当衍生反应以形成一系列取代的苯甲酰基胸腺嘧啶硫脲（BTTU）[IVa-f]和苯甲酰基胸苷脲（BTU）而合成的）[Va-f]。合成的化合物已通过1 H和13 C NMR，LC-MS和元素分析进行​​了表征。已经筛选了这些衍生物对红曲霉总血细胞计数的影响。已经观察到，通过氨基将取代的苯甲酰基硫脲和脲键引入到百里酚环中的活性高于母体化合物百里酚，并且与标准的昆虫生长调节剂Penfluron具有可比的结果。尿素[Va-f]化合物对总血细胞计数（THC）的影响大于硫脲[IVa-f]。氟取代比氯取代的化合物对THC的增强作用更大，而邻位取代的效果优于对位取代。本文描述的结果是有希望的，并提供了可用作昆虫生长调节剂的一系列新的合成化学物质。

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  • 来源
    《Journal of environmental science and health》 |2012年第2期|p.136-143|共8页
  • 作者

    CHETAN M. ZADE; UMESH D. PETE; SMITA S. PATIL; JITENDRA D. BHOSALE; CHAKRADHAR D.HADOLE; MEGHRAJ S. KADAM; RATNAMALA S. BENDRE;

  • 作者单位

    School of Chemical Sciences, North Maharashtra University, Umavinagar, Jalgaon, India;

    School of Chemical Sciences, North Maharashtra University, Umavinagar, Jalgaon, India;

    School of Chemical Sciences, North Maharashtra University, Umavinagar, Jalgaon, India;

    School of Chemical Sciences, North Maharashtra University, Umavinagar, Jalgaon, India;

    School of Chemical Sciences, North Maharashtra University, Umavinagar, Jalgaon, India;

    School of Life Sciences, North Maharashtra University, Umavinagar, Jalgaon, India;

    School of Chemical Sciences, North Maharashtra University, Umavinagar, Jalgaon, India,Department of Pesticides & Agrochemicals, School of Chemical Sciences, P.O.Box No. 80, Umavinagar, North Maharashtra University, Jalgaon 425 001, (M.S.), India;

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  • 关键词

    thymol; benzoyl thymyl thioureas; benzoyl thymyl ureas; total haemocyte count (THC);

    机译：百里香酚苯甲酰基胸苷硫脲;苯甲酰基胸苷脲;总血细胞计数（THC）;

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