...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of environmental science and health >Synthesis of 2-furyl-4-arylidene-5(4H)-oxazolones as new potent antibacterial agents against phyto-pathogenic and nitrifying bacteria
【24h】

Synthesis of 2-furyl-4-arylidene-5(4H)-oxazolones as new potent antibacterial agents against phyto-pathogenic and nitrifying bacteria

机译：新型2-呋喃基-4-亚芳基-5（4H）-恶唑酮类化合物对植物病原菌和硝化细菌的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Crop losses due to bacterial pathogens are a major global concern. Most of the available pesticides for these pathogens suffer from various drawbacks such as complicated synthesis, high cost, high toxicity, pesticide resistance and environmental hazards. To overcome these drawbacks, the present study was undertaken to find a potent bactericide. Therefore, a series of compounds comprising bioactive furyl and oxazolone rings was synthesized under microwave irradiation and screened for in vitro antibacterial activity. The reactions were completed in fewer than 2 minutes with minimal use of solvents and resulted in high yields. These compounds were screened for antibacterial activity against plant pathogens, Xanthomonas oryzae, Ralstonia solanacearum and nitrifying bacteria, Nitrosomonas species under laboratory conditions. Five compounds were active as antibacterial agents against Xanthomonas oryzae and Ralstonia solanacearum. However, all compounds were effective against the Nitrosomonas species and the best one was 2-furyl-4-(3-methoxy-4-hydroxybenzylidene)-5(4H)-oxazolone. The study revealed the fast and environmentally friendly synthesis of bioactive title compounds, which also hold promise to be used as prototypes for the discovery of potent analogues.
机译：由于细菌病原体引起的作物损失是全球主要关注的问题。用于这些病原体的大多数可用农药具有各种缺点，例如合成复杂，成本高，毒性高，对农药的抗性和对环境的危害。为了克服这些缺点，进行了本研究以发现有效的杀菌剂。因此，在微波辐射下合成了包含生物活性呋喃基和恶唑酮环的一系列化合物，并筛选了其体外抗菌活性。反应在不到2分钟的时间内完成，使用了最少的溶剂，收率很高。在实验室条件下，筛选了这些化合物对植物病原体，米氏黄单胞菌，青枯雷尔氏菌和硝化细菌，亚硝化单胞菌的抗菌活性。五种化合物具有作为活性的米黄单胞菌和青枯雷尔氏菌的抗菌剂。但是，所有化合物均对亚硝化单胞菌有效，最好的化合物是2-呋喃基-4-（3-甲氧基-4-羟基亚苄基）-5（4H）-恶唑酮。这项研究揭示了生物活性标题化合物的快速，环保合成方法，也有望用作发现有效类似物的原型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号