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首页> 外文期刊>Journal of Environmental Science and Health >Evaluation of antibacterial efficacy of sulfur nanoparticles alone and in combination with antibiotics against multidrug-resistant uropathogenic bacteria
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Evaluation of antibacterial efficacy of sulfur nanoparticles alone and in combination with antibiotics against multidrug-resistant uropathogenic bacteria

机译：硫纳米颗粒单独和与抗生素联合使用对多药耐药性尿路致病菌的抗菌效果评估

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摘要

Urinary tract infections (UTIs) have been frequently reported from different parts of the world. The current knowledge on distribution of causative agents of urinary infections and antibiotics susceptibility pattern is essentially required. In the present study, total 351 uropathogenic bacteria were isolated; among them most prevalent were Escherichia coli (75%), followed by Pseudomonas aeruginosa (8%), Proteus mirabilis (6%), Klebsiella pneumoniae (4%), Staphylococcus aureus (4%) and Enterococcus faecalis (3%). Most isolates of uropathogenic bacteria showed resistance to amoxicillin and trimethoprim, followed by chloramphenicol and kanamycin. Biosynthesis of sulfur nanoparticles (SNPs) was performed by co-precipitation method using sodium thiosulfate in presence of Catharanthus roseus leaf extract. The characterization data showed that SNPs were polydispersed, spherical in shape with size range of 20-86nm and having negative zeta potential of -9.24mV. The potential antibacterial activity was observed for SNPs alone and in combination with antibiotics particularly amoxicillin and trimethoprim against majority of the uropathogens. The synergistic effect yielded increase in fold area with high activity index against tested uropathogens. Based on overall results, it can be recommended to use SNPs for the management of UTI alone and also in combination with antibiotics.
机译：泌尿道感染（UTI）经常在世界各地报道。基本上需要有关泌尿道感染的病原体分布和抗生素敏感性模式的最新知识。在本研究中，共分离出351个尿路致病菌；其中最普遍的是大肠杆菌（75％），其次是铜绿假单胞菌（8％），奇异变形杆菌（6％），肺炎克雷伯菌（4％），金黄色葡萄球菌（4％）和粪肠球菌（3％）。多数尿路致病菌分离株对阿莫西林和甲氧苄啶具有抗性，其次是氯霉素和卡那霉素。在长春花叶提取物存在下，使用硫代硫酸钠通过共沉淀法进行硫纳米颗粒（SNPs）的生物合成。表征数据表明，SNP是多分散的，呈球形，大小范围为20-86nm，负ζ电势为-9.24mV。单独和与抗生素（尤其是阿莫西林和甲氧苄氨嘧啶）合用的SNP对大多数尿路致病菌均观察到了潜在的抗菌活性。协同作用产生了倍数增加的折叠面积，并具有针对测试的尿路致病菌的高活性指数。根据总体结果，建议将SNP单独用于尿路感染，也可与抗生素联合使用。

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