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首页> 外文期刊>Journal of Environmental Science and Health >In vivo effect confirmation of anti-androgenic compounds in sediment contact tests with Potamopyrgus antipodarum
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In vivo effect confirmation of anti-androgenic compounds in sediment contact tests with Potamopyrgus antipodarum

机译：在与Potamopyrgus antipodarum的沉积物接触测试中抗雄激素化合物的体内效应确认

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摘要

In order to investigate the sensitivity of Potamopyrgus antipodarum to anti-androgenic compounds, three spiked sediment tests were performed. The substances benzanthrone (7H-benz[de]anthracen-7-one), traseolide (ATII) and androstenone (5α-Androst-16-en-3-one) were previously identified in an effect-directed analysis study of the river Schijn in the north of Belgium. Although, in previous studies, all of the three compounds exhibited anti-androgenic activities in vitro, only the oxy-PAH benzanthrone had significant stimulating effects on the snails' reproduction. The reproduction of P. antipodarum was significantly stimulated, following a sigmoidal dose response curve, whereby an EC_(50) of 10 ng/g dry sediment was calculated. Mortality was significantly increased at the highest concentration (69 ng/g dry sediment). The results indicate different relative potencies for the in vivo test with P. antipodarum and the in vitro anti-AR-CALUX assay, performed in a previous study. This highlights the importance of combined in vitro and in vivo assays for the effect assessment of field sediments.
机译：为了研究抗腐雄性补牙草（Potamopyrgus antipodarum）对抗雄激素化合物的敏感性，进行了三次加标沉降试验。先前已在Schijn河的效果定向分析研究中确定了苯并蒽酮（7H-苯并蒽-7-one），曲沙奈德（ATII）和雄烯酮（5α-Androst-16-en-3-one）物质。在比利时北部。尽管在以前的研究中，这三种化合物均在体外表现出抗雄激素活性，但只有氧基-PAH苯并蒽醌对蜗牛的繁殖具有显着的刺激作用。遵循S形剂量响应曲线，大大刺激了P. antipodarum的繁殖，从而计算出EC_（50）为10 ng / g干沉积物。在最高浓度（69 ng / g干沉积物）下，死亡率显着增加。结果表明在先前的研究中进行的抗疟原虫体内测试和体外抗AR-CALUX检测的相对相对效力不同。这突出了结合体外和体内测定法对田间沉积物效果评估的重要性。

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  • 来源
    《Journal of Environmental Science and Health》 |2013年第6期|475-480|共6页
  • 作者

    CLAUDIA SCHMITT; MARJA LAMOREE; PIM LEONARDS; JANA M. WEISS; ERIC DE DECKERE;

  • 作者单位

    University of Antwerp, SPHERE, Antwerp, Belgium ,University of Antwerp, Groenenborgerlaan 171, BE-2020, Antwerpen, Belgium;

    VU University Amsterdam, Institute for Environmental Studies, Amsterdam, The Netherlands;

    VU University Amsterdam, Institute for Environmental Studies, Amsterdam, The Netherlands;

    VU University Amsterdam, Institute for Environmental Studies, Amsterdam, The Netherlands;

    University of Antwerp, Institute of Environment and Sustainable Development, Wilrijk, Belgium;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Traseolide; androstenone; benzanthrone; reproduction; Prosobranch snails;

    机译：假期假期;雄烯酮苯并蒽醌再生产;亲蜗牛;

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