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首页> 外文期刊>Journal of Environmental Science and Health. A, Toxic/Hazardous Substances & Environmental Engineering >Uptake and Elimination of Naphthalene from Liver, Lung, and Muscle Tissue in the Leopard frog (Rana pipiens)
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Uptake and Elimination of Naphthalene from Liver, Lung, and Muscle Tissue in the Leopard frog (Rana pipiens)

机译：豹蛙（Rana pipiens）肝脏，肺和肌肉组织中萘的摄取和消除

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摘要

The effects of a 0-12-hour naphthalene exposure on pulmonary CO_2 excretion and bioaccumulation in the leopard frog, Rana pipiens, were investigated. The data showed that naphthalene transport occurred from the aqueous phase into the frog tissue. The first-order rate constant (k in day~(-1)) for the entry of naphthalene from the water into the frog was 0.079 ± 0.007 (k ± 95% C.I.). Bioaccumulation of naphthalene was measured in liver, lung, and thigh muscle tissue. Exposure to naphthalene caused a significant reduction in pulmonary CO_2 excretion, particularly following the first 30 minutes of exposure. Pulmonary CO_2 excretion returned to baseline levels after 8 hours of exposure, indicating that some degree of acclimation had occurred. Depuration experiments were used to monitor recovery from naphthalene exposure. Recovery of CO_2 excretion was evident following 2 hours of depuration and complete elimination of naphthalene from tissues occurred after 3 hours. The data indicate that accumulated polycyclic aromatic hydrocarbons (PAHs) may alter normal physiologic functions such as gas exchange. Since amphibians, such as frogs, are one of the first organisms to come into contact with contaminated water and sediments, the information in this study suggests that this species may be used to assess bioaccumulation and toxicity of PAHs in ecosystems.
机译：研究了暴露0-12小时的萘对豹蛙Rpi pipiens的肺CO_2排泄和生物积累的影响。数据显示萘从水相转移到青蛙组织中。萘从水中进入青蛙的一级速率常数（k天（-1）中的k）为0.079±0.007（k±95％C.I.）。在肝，肺和大腿肌肉组织中测量萘的生物蓄积。暴露于萘导致肺部CO_2排泄显着减少，尤其是在暴露的前30分钟之后。暴露8小时后，肺CO_2排泄恢复到基线水平，表明已经发生一定程度的适应。净化实验用于监测萘暴露的回收率。净化2小时后，CO_2排泄的恢复很明显，并且3小时后从组织中完全清除了萘。数据表明积累的多环芳烃（PAHs）可能会改变正常的生理功能，例如气体交换。由于两栖动物（如青蛙）是最早与受污染的水和沉积物接触的生物之一，因此本研究中的信息表明，该物种可用于评估生态系统中PAHs的生物积累和毒性。

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