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首页> 外文期刊>Journal of Experimental Botany >MGOUN3: evidence for chromatin-mediated regulation of FLC expression
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MGOUN3: evidence for chromatin-mediated regulation of FLC expression

机译：MGOUN3：染色质介导的FLC表达调控的证据

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摘要

The MGOUN3(MGO3)/BRUSHY1(BRU1)/TONSOKU(TSK) gene of Arabidopsis thaliana encodes a nuclear leucine–glycine–asparagine (LGN) domain protein that may be implicated in chromatin dynamics and genome maintenance. Mutants with defects in MGO3 display a fasciated stem and disorganized meristem structures. The transition to flowering was examined in mgo3 mutants and it was found that, under short days, the mutants flowered significantly earlier than the wild-type plants. Study of flowering-time associated gene expression showed that the floral transition inhibitor gene FLC was under-expressed in the mutant background. Ectopic expression of the flower-specific genes AGAMOUS (AG), PISTILLATA (PI), and SEPALLATA3 (SEP3) in mgo3 vegetative organs was also detected. Western blot and chromatin immunoprecipitation experiments suggested that histone H3 acetylation may be altered in the mgo3 background. Together, these data suggest that MGO3 is required for the correct transition to flowering and that this may be mediated by histone acetylation and associated changes in FLC expression.
机译：拟南芥的MGOUN3（MGO3）/ BRUSHY1（BRU1）/ TONSOKU（TSK）基因编码一种核亮氨酸-甘氨酸-天冬酰胺（LGN）域蛋白，可能与染色质动力学和基因组维护有关。 MGO3中有缺陷的突变体表现出茎杆松散和分生组织结构混乱。在mgo3突变体中检查了向开花的过渡，发现短时间内，突变体的开花时间明显早于野生型植物。开花时间相关基因表达的研究表明，在突变体背景中，花卉过渡抑制基因FLC的表达不足。还检测了在mgo3营养器官中花特异性基因AGAMOUS（AG），PISTILLATA（PI）和SEPALLATA3（SEP3）的异位表达。蛋白质印迹和染色质免疫沉淀实验表明，在mgo3背景中组蛋白H3乙酰化可能会改变。在一起，这些数据表明MGO3是正确过渡到开花所必需的，并且这可能由组蛋白乙酰化和FLC表达的相关变化介导。

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