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首页> 外文期刊>Journal of Experimental Marine Biology and Ecology >Parental environments alter DNA methylation in offspring of the purple sea urchin, Strongylocentrotus purpuratus
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Parental environments alter DNA methylation in offspring of the purple sea urchin, Strongylocentrotus purpuratus

机译：父母的环境改变了紫色海胆Strongylocentrotus purpuratus的后代DNA甲基化

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摘要

Phenotypic plasticity, within and across generations, is a strategy by which organisms can respond rapidly to environmental change. Epigenetic modifications, such as DNA methylation, have been proposed to be involved in phenotypic plasticity. We examined the potential for the environment to mediate both transgenerational and intragenerational plasticity in DNA methylation and phenotypes in early stages of the purple sea urchin, Strongylocentrotus purpuratus, an ecologically important herbivore in kelp forest ecosystems. This approach involved a controlled laboratory experiment where adult urchins were acclimated during gametogenesis to upwelling (similar to 1300 mu atm pCO(2) & 13 degrees C) or non-upwelling (similar to 650 mu atm pCO(2) & 17 degrees C) conditions that are representative of their kelp forest habitat. Progeny from these adults were raised in either high (similar to 1050 mu atm) or low (similar to 450 mu atm) pCO(2) treatments and sampled at three developmental stages. Differences in condition experienced by mothers were associated with differentially methylated genes in the offspring. However, differences in developmental conditions corresponded to little observable effects on gene methylation in the progeny. Variation in gene body methylation across treatments was correlated with body size of the embryos and larvae, illustrating a potential link between transgenerational phenotypic plasticity and DNA methylation. Overall, our results suggest that epigenetic factors such as DNA methylation have the potential to contribute to phenotypic plasticity in a transgenerational framework, and further, that epigenetic processes may act as a mechanism of rapid response to environmental change.
机译：表型可塑性在世代之间和世代之间是一种战略，生物体可以借此对环境变化迅速做出反应。已经提出表观遗传修饰，例如DNA甲基化，涉及表型可塑性。我们研究了环境在紫海胆（Stryylocentrotus purpuratus）早期阶段的环境中介导DNA甲基化和表型的跨代和代内可塑性的潜力，该海藻是海带森林生态系统中的重要生态草食动物。这种方法涉及一个受控的实验室实验，其中成年海胆在配子发生过程中适应上涌（类似于1300μatm pCO（2）和13摄氏度）或不上涌（类似于650μatm pCO（2）和17摄氏度）代表其海带森林栖息地的条件。这些成年人的后代在高pCO（2）处理（约1050微米大气压）或低（约450微米大气压）下生长，并在三个发育阶段进行采样。母亲所经历的状况差异与后代中甲基化基因的差异有关。但是，发育条件的差异对应于对子代中基因甲基化几乎没有可观察到的影响。整个处理过程中基因体甲基化的变化与胚胎和幼虫的体型相关，这说明了跨代表型可塑性与DNA甲基化之间的潜在联系。总体而言，我们的结果表明，表观遗传因素（例如DNA甲基化）可能会在跨代框架中促进表型可塑性，并且进一步，表观遗传过程可能充当对环境变化快速响应的机制。

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