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首页> 外文期刊>Journal of Experimental Marine Biology and Ecology >Parental environments alter DNA methylation in offspring of the purple sea urchin, Strongylocentrotus purpuratus
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Parental environments alter DNA methylation in offspring of the purple sea urchin, Strongylocentrotus purpuratus

机译：父母环境改变紫海胆，strondylocentrootus purpuratus后代的DNA甲基化

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摘要

Phenotypic plasticity, within and across generations, is a strategy by which organisms can respond rapidly to environmental change. Epigenetic modifications, such as DNA methylation, have been proposed to be involved in phenotypic plasticity. We examined the potential for the environment to mediate both transgenerational and intragenerational plasticity in DNA methylation and phenotypes in early stages of the purple sea urchin, Strongylocentrotus purpuratus, an ecologically important herbivore in kelp forest ecosystems. This approach involved a controlled laboratory experiment where adult urchins were acclimated during gametogenesis to upwelling (similar to 1300 mu atm pCO(2) & 13 degrees C) or non-upwelling (similar to 650 mu atm pCO(2) & 17 degrees C) conditions that are representative of their kelp forest habitat. Progeny from these adults were raised in either high (similar to 1050 mu atm) or low (similar to 450 mu atm) pCO(2) treatments and sampled at three developmental stages. Differences in condition experienced by mothers were associated with differentially methylated genes in the offspring. However, differences in developmental conditions corresponded to little observable effects on gene methylation in the progeny. Variation in gene body methylation across treatments was correlated with body size of the embryos and larvae, illustrating a potential link between transgenerational phenotypic plasticity and DNA methylation. Overall, our results suggest that epigenetic factors such as DNA methylation have the potential to contribute to phenotypic plasticity in a transgenerational framework, and further, that epigenetic processes may act as a mechanism of rapid response to environmental change.
机译：表型可塑性，内部和各地，是生物体可以迅速响应环境变化的策略。已经提出了表观遗传修饰，例如DNA甲基化，参与表型可塑性。我们研究了环境中的潜力，在紫脑血清素，Shiblyloctrotus purpuratus的早期阶段中的DNA甲基化和表型中介绍了转基因和肿瘤的可塑性，在海带森林生态系统中生态重要的食草动物。这种方法涉及受控实验室实验，其中成人核素在配子发生期间适应上升（类似于1300亩ATM PCO（2）＆13℃）或非升值（类似于650μmatPCO（2）＆17摄氏度）代表其海带森林栖息地的条件。这些成人的后代在高（类似于1050μmatm）或低（类似于450μmatm）的PCO（2）处理中，并在三个发育阶段进行采样。母亲所经历的病情差异与后代中的差异甲基化基因相关。然而，发育条件的差异对应于后代基因甲基化的几乎没有可观察的影响。在治疗中的基因体甲基化的变化与胚胎和幼虫的体尺寸相关，说明转基因表型可塑性和DNA甲基化之间的潜在连杆。总体而言，我们的结果表明，DNA甲基化等表观遗传因素具有转基因框架中的表型可塑性，并且进一步，表观遗传过程可以作为对环境变化的快速反应的机制。

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