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首页> 外文期刊>Journal of great lakes research >Effect of Exposure to Various Sites within Hamilton Harbour on Oncorhynchus mykiss Pronephros Macrophage Function and B Cell Numbers
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Effect of Exposure to Various Sites within Hamilton Harbour on Oncorhynchus mykiss Pronephros Macrophage Function and B Cell Numbers

机译：汉密尔顿港内不同地点的暴露对mycorsnchus mykiss前生巨噬细胞功能和B细胞数量的影响

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Our objective was to assess whether or not exposure to sites within Hamilton Harbour known to be highly contaminated with polycyclic aromatic hydrocarbons (PAHs), heavy metals, and sewage treatment plant (STP) effluent could affect macrophage function and B-cell numbers in fish. Caged rainbow trout (Oncorhynchus mykiss) were sampled after 7, 14, and 21 days of exposure to five harbor sites, plus a Lake Ontario reference site. Four of the harbor sites were selected for their proximity to either highly contaminated sediments or industrial and municipal discharges; the fifth site was selected as a harbor reference site. Pronephros leukocytes from fish at the six sites were evaluated for phagocytic activity, oxtdative burst, and the number of surface immunoglobulin-positive B cells. Although none of the immune parameters and B-cell numbers measured from fish that were caged at the contaminated harbor sites were significantly different from the harbor reference site, they were significantly different from the Lake Ontario reference site. Fish showed a greater reduction in pronephros leukocyte phagocytic activity over the course of the study when compared to the Lake Ontario reference fish; pronephros leukocyte oxidative burst was also reduced at two of the harbor sites. B cell counts did not change throughout the duration of the study, although overall counts were lower at two of the harbor sites when compared to the Lake Ontario site. The results indicate that macrophage function and B-cell numbers were altered in fish by exposure to various sites in Hamilton Harbour. The possible immunomodulatory roles of chemical and physical parameters at those sites are discussed.
机译：我们的目标是评估暴露于汉密尔顿港内已知被多环芳烃（PAHs），重金属和污水处理厂（STP）污水严重污染的场所是否会影响鱼类的巨噬细胞功能和B细胞数量。在暴露于五个港口站点以及安大略湖参考站点的第7、14和21天后，对笼中的虹鳟鱼（Oncorhynchus mykiss）进行了采样。选择了四个港口地点，以使其靠近高度污染的沉积物或工业和市政排放；第五个站点被选为港口参考站点。评估了这六个位置的鱼类的前线白细胞的吞噬活性，氧化爆发性和表面免疫球蛋白阳性B细胞的数量。尽管从被污染的港口地点关在笼中的鱼中测得的免疫参数和B细胞数量均与港口参考地点没有显着不同，但与安大略湖参考地点却没有显着不同。与安大略湖参考鱼相比，该鱼在研究过程中表现出前肾白细胞吞噬活性的更大降低。在两个港口位置，前肾白细胞的氧化爆发也减少了。尽管与安大略湖站点相比，两个港口站点的总计数较低，但B细胞计数在整个研究过程中并未发生变化。结果表明，通过暴露于汉密尔顿港的各个地点，鱼类中的巨噬细胞功能和B细胞数量发生了变化。讨论了这些部位的化学和物理参数可能的免疫调节作用。

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