Assessment on the toxicity and application risk of C4F7N: A new SF6 alternative gas

Li Yi; Zhang Xiaoxing; Zhang Ji; Xiao Song; Xie Baojuan; Chen Dachang; Gao Yadong; Tang Ju

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Assessment on the toxicity and application risk of C4F7N: A new SF6 alternative gas

机译：C4F7N的毒性和使用风险评估：一种新的SF6替代气体

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C4F7N (fluorinated nitrile) gas mixture has been utilized as the gas insulating medium to replace the most greenhouse gas SF6 (sulphur hexafluoride). Nowadays, there are few reports on the toxicity mechanism of C4F7N and studies on the application risk of C4F7N is insufficient. In this paper, we carried out acute toxicity tests for C4F7N gas systematically. The changes of vital signs of rats after exposure to C4F7N were analyzed and the influence of C4F7N on the main organs of rats was revealed for the first time. It was found that rats developed symptoms of respiratory rate decrease, respiratory mucosa damage, movement systems impairment and abnormal blood cell count after exposure to C4F7N. Pathological section results showed that 1.5% C4F7N could damage the lung, kidney, intestine and brain tissues of rats to a certain extent, but has little influence to the eye, skin, heart and liver. The LC50 (rat, 4 h) of C4F7N gas is in the range of 15,000 ppm (1.5%) and 20,000 ppm (2%). Relevant research results not only reveal the acute toxicity mechanism of C4F7N, but also provide important reference for the safety protection of scientific researcher, equipment production, engineering operation and maintenance personnel.

机译：C4F7N（氟化腈）气体混合物已被用作气体绝热介质，以替代大多数温室气体SF6（六氟化硫）。如今，关于C4F7N毒性机理的报道很少，关于C4F7N的使用风险的研究还不够。本文系统地对C4F7N气体进行了急性毒性试验。分析了C4F7N暴露后大鼠生命体征的变化，首次揭示了C4F7N对大鼠主要器官的影响。发现大鼠暴露于C4F7N后会出现呼吸频率降低，呼吸道粘膜损伤，运动系统受损和血细胞计数异常的症状。病理切片结果表明，1.5％的C4F7N可在一定程度上损害大鼠的肺，肾，肠和脑组织，但对眼睛，皮肤，心脏和肝脏的影响很小。 C4F7N气体的LC50（大鼠，4小时）在15,000 ppm（1.5％）和20,000 ppm（2％）的范围内。相关研究结果不仅揭示了C4F7N的急性毒性机理，而且为科研人员，设备生产，工程运维人员的安全防护提供重要参考。

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来源
《Journal of Hazardous Materials》 |2019年第15期|653-660|共8页
作者
Li Yi; Zhang Xiaoxing; Zhang Ji; Xiao Song; Xie Baojuan; Chen Dachang; Gao Yadong; Tang Ju;
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作者单位

Wuhan Univ, Sch Elect Engn, BaYi St 299, Wuhan 430072, Hubei, Peoples R China;

Wuhan Univ, Sch Elect Engn, BaYi St 299, Wuhan 430072, Hubei, Peoples R China;

Wuhan Univ, Sch Elect Engn, BaYi St 299, Wuhan 430072, Hubei, Peoples R China;

Wuhan Univ, Sch Elect Engn, BaYi St 299, Wuhan 430072, Hubei, Peoples R China;

Wuhan Univ, Zhongnan Hosp, Wuhan 430072, Peoples R China;

Wuhan Univ, Sch Elect Engn, BaYi St 299, Wuhan 430072, Hubei, Peoples R China;

Wuhan Univ, Zhongnan Hosp, Wuhan 430072, Peoples R China;

Wuhan Univ, Sch Elect Engn, BaYi St 299, Wuhan 430072, Hubei, Peoples R China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
C4F7N; Acute toxicity; Application risk; Pathological section; SF6 alternative gas;

机译：C4F7N;急性毒性;应用风险;病理切片;SF6替代气体;

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Assessment on the toxicity and application risk of C4F7N: A new SF6 alternative gas

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