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首页> 外文期刊>Journal of Hazardous Materials >Zinc oxide nanoparticles induce eosinophilic airway inflammation in mice
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Zinc oxide nanoparticles induce eosinophilic airway inflammation in mice

机译：氧化锌纳米颗粒诱导小鼠嗜酸性气道炎症

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摘要

Zinc oxide nanoparticles (ZnO NPs) have been widely used in industry. The metal composition of PM2.5 might contribute to the higher prevalence of asthma. To investigate the effects of ZnO NPs on allergic airway inflammation, mice were first exposed to different concentrations of ZnO NPs (0.1 mg/kg, 0.5 mg/kg) or to a combination of ZnO NPs and chicken egg ovalbumin (OVA) by oropharyngeal aspiration on day 0 and day 7 and then were sacrificed 5 days later. The subsequent time course of airway inflammation in the mice after ZnO NPs exposure was evaluated on days 1, 7, and 14. To further determine the role of zinc ions, ZnCl2 was also administered. The inflammatory cell count, cytokine levels in the bronchoalveolar lavage fluid (BALF), and lung histopathology were examined. We found significant neutrophilia after exposure to high-dose ZnO NPs on day 1 and significant eosinophilia in the BALF at 7 days. However, the expression levels of the T helper 2 (Th2) cytokines IL-4, IL-5, and IL-13 increased significantly after 24h of exposure to only ZnO NPs and then decreased gradually. These results suggested that ZnO NPs could cause eosinophilic airway inflammation in the absence of allergens. (C) 2015 Elsevier B.V. All rights reserved.
机译：氧化锌纳米颗粒（ZnO NPs）已广泛用于工业中。 PM2.5的金属成分可能导致哮喘患病率更高。为了研究ZnO NPs对过敏性气道炎症的影响，首先通过口咽抽吸将小鼠暴露于不同浓度的ZnO NPs（0.1 mg / kg，0.5 mg / kg）或ZnO NPs与鸡蛋卵清蛋白（OVA）的组合中在第0天和第7天，然后在5天后处死。在第1、7和14天评估了ZnO NPs暴露后小鼠气道炎症的后续时间进程。为了进一步确定锌离子的作用，还施用了ZnCl2。检查炎症细胞计数，支气管肺泡灌洗液（BALF）中的细胞因子水平以及肺组织病理学。在第1天暴露于高剂量ZnO NP后，我们发现了明显的嗜中性粒细胞，而在第7天在BALF中发现了明显的嗜酸性粒细胞。但是，仅暴露于ZnO NP后24小时，T辅助2（Th2）细胞因子IL-4，IL-5和IL-13的表达水平显着增加，然后逐渐降低。这些结果表明，在没有过敏原的情况下，ZnO NPs可能引起嗜酸性气道炎症。 （C）2015 Elsevier B.V.保留所有权利。

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  • 来源
    《Journal of Hazardous Materials》 |2015年第30期|304-312|共9页
  • 作者

    Huang Kuo-Liang; Lee Yi-Hsin; Chen Hau-Inh; Liao Huang-Shen; Chiang Bor-Luen; Cheng Tsun-Jen;

  • 作者单位

    Natl Taiwan Univ, Inst Occupat Med & Ind Hyg, Coll Publ Hlth, Taipei 10764, Taiwan|Taipei Tzu Chi Hosp, Div Pulm Med, Buddhist Tzu Chi Med Fdn, New Taipei City, Taiwan;

    Taipei Tzu Chi Hosp, Dept Pathol, Buddhist Tzu Chi Med Fdn, New Taipei City, Taiwan;

    Taipei Tzu Chi Hosp, Dept Res, Buddhist Tzu Chi Med Fdn, New Taipei City, Taiwan;

    Taipei Tzu Chi Hosp, Dept Lab Med, Buddhist Tzu Chi Med Fdn, New Taipei City, Taiwan;

    Natl Taiwan Univ, Grad Inst Immunol, Taipei 10764, Taiwan;

    Natl Taiwan Univ, Inst Occupat Med & Ind Hyg, Coll Publ Hlth, Taipei 10764, Taiwan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Asthma; Eosinophilic airway inflammation; Zinc oxide nanoparticles;

    机译：哮喘;嗜酸性气道炎症;氧化锌纳米粒子;

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