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首页> 外文期刊>Journal of Hazardous Materials >Methionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study
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Methionine oxidation in albumin by fine haze particulate matter: An in vitro and in vivo study

机译：细雾状颗粒物质使白蛋白中的蛋氨酸氧化：体内和体外研究

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摘要

The potential effects of inhaled fine particulate matter (PM_(2.5)), found in haze episodes, on the oxidation of the proteins in the lungs are not well understood. We investigated the effects of PM_(2.5) from haze episodes on protein oxidation. PM_(2.5) was collected from the air pollution in Beijing (BJ), Xian (XA), Xiamen (XM) and Hong Kong (HK) during a period of intensive haze episodes. The chemical characteristics of these samples and their effects on albumin oxidation were investigated. The levels of PM_(2.5) in BJ and XA were 4-6 times higher than in XM and HK. The concentrations of the polycyclic aromatic hydrocarbons (PAHs) components of the PM_(2.5) from BJ and XA were 10 times higher than those found in XM and HK. The haze PM_(2.5) increased oxidative stress. Addition of PM_(2.5) samples collected from haze episodes to albumin in vitro resulted in oxidation of methionine moieties; nasal instillation of PM_(2.5) suspensions in mice resulted in oxidation of methionine in the albumin in the bronchoalveolar lavage fluid. The methionine moieties participate in peptide chain crosslinking, and methionine oxidation in the albumin could be attributed to the PAH compounds. Our findings may be helpful in explaining the potential respiratory effects during haze episodes.
机译：在雾霾发作中发现的吸入细颗粒物（PM_（2.5））对肺部蛋白质氧化的潜在影响尚不清楚。我们调查了霾事件中的PM_（2.5）对蛋白质氧化的影响。 PM_（2.5）是在强烈雾霾发作期间从北京（BJ），西安（XA），厦门（XM）和香港（HK）的空气污染中收集的。研究了这些样品的化学特性及其对白蛋白氧化的影响。 BJ和XA中的PM_（2.5）水平比XM和HK中的PM_（2.5）高4-6倍。来自BJ和XA的PM_（2.5）的多环芳烃（PAHs）成分的浓度比XM和HK中的多环芳烃的浓度高10倍。雾霾PM_（2.5）增加了氧化应激。从霾事件中采集的PM_（2.5）样品在体外添加到白蛋白中会导致蛋氨酸部分的氧化；鼻腔滴注PM_（2.5）悬浮液会导致支气管肺泡灌洗液中白蛋白中的蛋氨酸氧化。蛋氨酸部分参与肽链交联，并且白蛋白中的蛋氨酸氧化可能归因于PAH化合物。我们的发现可能有助于解释霾事件中潜在的呼吸作用。

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  • 来源
    《Journal of Hazardous Materials》 |2014年第15期|384-391|共8页
  • 作者

    Kang-Yun Lee; Chris Kong-Chu Wong; Kai-Jen Chuang; Mauo-Ying Bien; Jun-Ji Cao; Yong-Ming Han; Linwei Tian; Chih-Cheng Chang; Po-Hao Feng; Kin-Fai Ho; Hsiao-Chi Chuang;

  • 作者单位

    School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan,Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan;

    State Key Laboratory in Marine Pollution-Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China;

    School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan,Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;

    School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan,Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan;

    Key Lab of Aerosol Science & Technology, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710075, China;

    Key Lab of Aerosol Science & Technology, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710075, China;

    The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China;

    Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan;

    Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan;

    The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China;

    School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan,Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Air pollution; Liquid chromatography-mass spectrometry; Polycyclic aromatic hydrocarbons; Protein structure; Pulmonary;

    机译：空气污染;液相色谱-质谱联用;多环芳烃;蛋白质结构;肺的;

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