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首页> 外文期刊>Journal of Hazardous Materials >Genotoxic biomonitoring of tobacco farmers: Biomarkers of exposure, of early biological effects and of susceptibility
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Genotoxic biomonitoring of tobacco farmers: Biomarkers of exposure, of early biological effects and of susceptibility

机译：烟农的遗传毒性生物监测：接触，早期生物效应和药敏性的生物标志

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摘要

Tobacco farming presents several hazards to those who cultivate and harvest the plant. The genotoxic and mutagenic effects in tobacco farmers were investigated. In order to verify the relationship between genetic susceptibility and biomarkers GSTT1, GSTM1, GSTP1, CYP2A6, PON, OGG1, RAD51,XRCC1, and XRCC4 genes polymorphism were evaluated. Oxidative stress markers and trace elements content were determined. Peripheral blood cells samples were collected from 111 agricultural workers during pesticides application and leaf harvest, and 56 non-exposed subjects. Results show that farmers are exposed to mixture of substances with genotoxic and cytotoxic potential. Only GSTM1 null and CYP2A6~*9 showed significant associations with cytokinesis-blocked micronuclei assay results. In pesticide application an increase in trace elements content was observed. The results indicated that exposure to pesticides and nicotine can influence antioxidant enzymes activity. Our study drives the attention once more to the need for occupational training on safe work environment for farm workers.
机译：烟草种植对那些种植和收割该植物的人构成了若干危害。调查了烟农的遗传毒性和诱变作用。为了验证遗传易感性与生物标记之间的关系，对GSTT1，GSTM1，GSTP1，CYP2A6，PON，OGG1，RAD51，XRCC1和XRCC4基因多态性进行了评估。测定了氧化应激标志物和微量元素的含量。在施药和收获叶片期间，从111名农业工人和56名未暴露的受试者中采集了外周血细胞样本。结果表明，农民暴露于具有遗传毒性和细胞毒性潜力的混合物中。只有GSTM1 null和CYP2A6〜* 9与胞质分裂阻滞的微核检测结果显着相关。在农药施用中，观察到微量元素含量的增加。结果表明，接触农药和尼古丁会影响抗氧化酶的活性。我们的研究再次将注意力转移到对农场工人安全工作环境进行职业培训的必要性上。

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  • 来源
    《Journal of Hazardous Materials》 |2012年第30期|p.81-90|共10页
  • 作者

    Fernanda Rabaioli Da Silva; Juliana Da Silva; Mariangela da C. Allgayer; Caroline F. Simon; Johnny F. Dias; Carla E.I. dos Santos; Mirian Salvador; Catia Branco; Naye Balzan Schneider; Vivian Kahl; Paula Rohr; Katia Kvitko;

  • 作者单位

    Postgraduate Program in Genetics and Molecular Biology (PPGBM), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil;

    Laboratory of Genetic Toxicology, Postgraduate Program in Celular and Molecular Biology Applied to Health (PPGBioSaude), Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil;

    Veterinary Clinical Pathology Laboratory, Lutheran University of Brazil, 92425-900 Canoas, RS, Brazil;

    Veterinary Clinical Pathology Laboratory, Lutheran University of Brazil, 92425-900 Canoas, RS, Brazil;

    School of Physics, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;

    School of Physics, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;

    Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil;

    Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil;

    Postgraduate Program in Genetics and Molecular Biology (PPGBM), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil;

    Laboratory of Genetic Toxicology, Postgraduate Program in Celular and Molecular Biology Applied to Health (PPGBioSaude), Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil;

    Postgraduate Program in Genetics and Molecular Biology (PPGBM), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil;

    Postgraduate Program in Genetics and Molecular Biology (PPGBM), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    comet assay; micronucleus test; tobacco farmers; pesticides; nicotine; genetic polymorphism;

    机译：彗星试验微核试验烟农农药尼古丁;遗传多态性;

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