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首页> 外文期刊>Journal of Hazardous Materials >Pre-irradiation of anatase TiO_2 particles with UV enhances their cytotoxic and genotoxic potential in human hepatoma HepG2 cells
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Pre-irradiation of anatase TiO_2 particles with UV enhances their cytotoxic and genotoxic potential in human hepatoma HepG2 cells

机译：紫外线预辐照锐钛矿型TiO_2颗粒可增强其在人肝癌HepG2细胞中的细胞毒性和遗传毒性

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摘要

Titanium dioxide (TiO_2) is active in the UV region of the light spectra and is used as a photocatalyst in numerous applications. Photo-activated anatase TiO_2 particles promote increased production of free radicals. This is a desirable property, although the potential toxicity of such photo-activated TiO_2 particles on exposure of humans and the environment remains unknown. Therefore, we studied whether pre-irradiation of TiO_2 particles with UV influences their cytotoxic and genotoxic potential. The TiO_2 particles, as TiO_2-A (<25nm) and TiO_2-B (>100nm), were UV pre-irradiated (24h) and tested for cytotoxic and genotoxic activities in human hepatoma HepG2 cells. Non-irradiated TiO_2-A/B at 1.0-250 μg/ml did not reduce viability of HepG2 cells, nor induce significant increases in DNA strand breaks; only TiO_2-A induced significant increases in oxidative DNA damage. After UV pre-irradiation, both TiO_2-A and TiO_2-B reduced cell viability and induced significant increases in DNA strand breaks and oxidative DNA damage. This is the first study that shows that UV pre-irradiation of anatase TiO_2 particles results in increased cytotoxic and genotoxic potential. This warrants further studies as it has important implications for environmental and human health risk assessment and preventive actions to limit human exposure.
机译：二氧化钛（TiO_2）在光谱的UV区域内具有活性，并在许多应用中用作光催化剂。光活化的锐钛矿TiO_2颗粒促进自由基产生的增加。尽管这种光活化的TiO 2颗粒对人类和环境的潜在毒性仍然未知，但这是理想的性质。因此，我们研究了用紫外线预照射TiO_2颗粒是否影响其细胞毒性和遗传毒性。预先对TiO_2颗粒（如TiO_2-A（<25nm）和TiO_2-B（> 100nm））进行紫外线辐射（24h），并测试其在人肝癌HepG2细胞中的细胞毒性和遗传毒性。未经辐照的TiO_2-A / B浓度为1.0-250μg/ ml不会降低HepG2细胞的活力，也不会引起DNA链断裂的显着增加。只有TiO_2-A引起氧化DNA损伤的明显增加。在紫外线预辐照后，TiO_2-A和TiO_2-B均降低了细胞活力，并引起DNA链断裂和氧化DNA损伤的明显增加。这是第一项显示锐钛矿型TiO_2颗粒的紫外线预辐照导致细胞毒性和遗传毒性增加的研究。这值得进一步研究，因为它对环境和人类健康风险评估以及限制人类接触的预防措施具有重要意义。

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  • 来源
    《Journal of Hazardous Materials》 |2011年第2011期|p.145-152|共8页
  • 作者

    Jana Petkovic; Tadeja Kuezma; Katja Rade; Sasa Novak; Metka Filipic;

  • 作者单位

    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, SI-1000 Ljubljana, Slovenia;

    Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia;

    Department for Nanostructured Materials, foief Stefan Institute, Jamova c. 39, SI-1000 Ljubljana, Slovenia;

    Department for Nanostructured Materials, foief Stefan Institute, Jamova c. 39, SI-1000 Ljubljana, Slovenia;

    Department for Genetic Toxicology and Cancer Biology, National Institute of Biology, Vecna pot 111, SI-1000 Ljubljana, Slovenia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    anatase TiO_2; cytotoxicity; genotoxicity; photocatalytic; HepG2 cells;

    机译：锐钛矿型TiO_2;细胞毒性遗传毒性光催化HepG2细胞;

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