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首页> 外文期刊>Journal of Heredity >Probabilistic Expert Systems for Forensic Inference from DNA Markers in Horses: Applications to Confirm Genealogies with Lack of Genetic Data
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Probabilistic Expert Systems for Forensic Inference from DNA Markers in Horses: Applications to Confirm Genealogies with Lack of Genetic Data

机译：从马中DNA标记进行法医推断的概率专家系统：缺乏遗传数据的家谱确认应用

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摘要

Microsatellites have been used for parentage testing and individual identification in forensic science because they are highly polymorphic and show abundant sequences dispersed throughout most eukaryotic nuclear genomes. At present, genetic testing based on DNA technology is used for most domesticated animals, including horses, to confirm identity, to determine parentage, and to validate registration certificates. But if genetic data of one of the putative parents are missing, verifying a genealogy could be questionable. The aim of this paper is to illustrate a new approach to analyze complex cases of disputed relationship with microsatellites markers. These cases were solved by analyzing the genotypes of the offspring and other horses’ genotypes in the pedigrees of the putative dam/sire with probabilistic expert systems (PESs). PES was especially efficient in supplying reliable, error-free Bayesian probabilities in complex cases with missing pedigree data. One of these systems was developed for forensic purposes (FINEX program) and is particularly valuable in human analyses. We applied this program to parentage analysis in horses, and we will illustrate how different cases have been successfully worked out.
机译：微卫星已被用于法医科学中的亲子鉴定和个体鉴定，因为它们具有高度的多态性，并显示出遍布整个真核生物核基因组的丰富序列。目前，基于DNA技术的基因检测已用于包括马在内的大多数家养动物中，以确认身份，确定父母身份并验证注册证书。但是，如果缺少一个假定父母的遗传数据，则验证家谱可能会令人怀疑。本文的目的是说明一种新方法，用于分析与微卫星标记有争议关系的复杂案例。通过使用概率专家系统（PES）分析假定水坝/父系的后代和其他马的基因型，解决了这些情况。在缺少谱系数据的复杂情况下，PES在提供可靠，无错误的贝叶斯概率方面特别有效。这些系统之一是为法证目的而开发的（FINEX程序），在人体分析中特别有价值。我们将此程序应用于马的亲子关系分析，并将说明如何成功解决不同的情况。

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