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首页> 外文期刊>Journal of Inflammation >Protective effect of Zhuyeqing liquor, a Chinese traditional health liquor, on acute alcohol-induced liver injury in mice
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Protective effect of Zhuyeqing liquor, a Chinese traditional health liquor, on acute alcohol-induced liver injury in mice

机译：传统保健酒竹叶清液对小鼠急性酒精性肝损伤的保护作用

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摘要

The study first evaluated the hepatoprotective effect of Zhuyeqing Liquor (ZYQL) against acute alcohol-induced liver injury in mice. Animals were administered orally with 50% alcohol 12ml/kg at 4h after the doses of ZYQL everyday for fourteen consecutive days except mice in normal group. The protective effect was evaluated by biochemical parameters including serum aspartate transaminase (AST), alanine transferase (ALT), total-bilirubin (TBIL) and reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) in liver tissue. The result were confirmed histopathologically and the expression of TNF-α in mice liver was determined by immunohistochemistry analysis. HPLC-PDA was used for phytochemical analysis of ZYQL, and the plant source of each compound was claritied by UPLC-TOF-MS. The result showed that pretreatment with ZYQL exhibited a significant protective effect by reversing the biochemical parameters and histopathological changes in a dose depended manner. HPLC analysis indicated that ZYQL contained flavonoids, iridoids, terpenoids and phenolic acids, which might be the active chemicals. This study demonstrated the hepatoprotective activity of ZYQL, thus scientifically supported the function of its health care.
机译：该研究首先评估了猪野清酒（ZYQL）对小鼠急性酒精性肝损伤的肝保护作用。除正常组的小鼠外，在每天ZYQL剂量后4h，连续14天给动物口服50％酒精12ml / kg。通过生化参数评估保护作用，这些参数包括肝组织中的血清天冬氨酸转氨酶（AST），丙氨酸转移酶（ALT），总胆红素（TBIL）和还原型谷胱甘肽（GSH），丙二醛（MDA），超氧化物歧化酶（SOD）。病理证实了该结果，并通过免疫组织化学分析确定了小鼠肝脏中TNF-α的表达。 HPLC-PDA用于ZYQL的植物化学分析，并通过UPLC-TOF-MS阐明每种化合物的植物来源。结果表明，ZYQL预处理通过逆转生化参数和剂量依赖性的组织病理学变化表现出显着的保护作用。 HPLC分析表明，ZYQL含有黄酮类化合物，烯酮类化合物，萜类化合物和酚酸，可能是活性化学品。这项研究证明了ZYQL的保肝活性，因此在科学上支持其保健功能。

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