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Zirconium Based Nano Metal-Organic Framework UiO-67-NH_2 with High Drug Loading for Controlled Release of Camptothecin

机译:基于锆的纳米金属有机框架UiO-67-NH_2具有较高的载药量,可喜树碱的控释

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摘要

A zirconium-based nano metal-organic framework (NMOF) UiO-67-NH2 was prepared solvothermally using shape modifier triethylamine. Its loading capacity for topoisomerase inhibitor compound camptothecin (CPT) was investigated. The structure and CPT loading properties of UiO-67-NH2 were assessed with the help of X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and high-performance liquid chromatography (HPLC). The XRD and SEM results indicated the successful synthesis of the nano-sized UiO-67-NH2. Further, FTIR spectroscopy indicated that UiO-67-NH2 could be loaded with CPT. Also, the HPLC experiments revealed that nano-sized UiO-67-NH2 shows high CPT loading capacity of up to 36.53 wt%.
机译:使用形状改性剂三乙胺溶剂热法制备了锆基纳米金属有机骨架(NMOF)UiO-67-NH2。研究了其对拓扑异构酶抑制剂化合物喜树碱(CPT)的负载能力。通过X射线衍射(XRD),扫描电子显微镜(SEM),傅立叶变换红外光谱(FTIR)和高效液相色谱(HPLC)评估了UiO-67-NH2的结构和CPT负载特性。 XRD和SEM结果表明成功合成了纳米尺寸的UiO-67-NH2。此外,FTIR光谱表明UiO-67-NH2可以装载CPT。同样,HPLC实验表明,纳米级的UiO-67-NH2显示出高达36.53 wt%的高CPT负载能力。

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    Guangxi Univ Nationalities Guangxi Key Lab Chem & Engn Forest Prod Guangxi Univ Nationalities Coll Chem & Chem Engn Nanning 530006 Guangxi Peoples R China;

    Univ Lucknow Fac Sci Dept Chem Lucknow 226007 Uttar Pradesh India;

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  • 正文语种 eng
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  • 关键词

    NMOF; Camptothecin; Drug loading;

    机译:NMOF;喜树碱;载药量;

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