• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >ATP-Responsive Aptamer-Based Metal-Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs
【24h】

ATP-Responsive Aptamer-Based Metal-Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs

机译：基于ATP响应适体的金属有机骨架纳米颗粒（NMOF），用于控制释放药物和药物

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nanoparticles consisting of metal-organic frameworks (NMOFs) modified with nucleic acid binding strands are synthesized. The NMOFs are loaded with a fluorescent agent or with the anticancer drug doxorubicin, and the loaded NMOFs are capped by hybridization with a complementary nucleic acid that includes the ATP-aptamer or the ATP-AS1411 hybrid aptamer in caged configurations. The NMOFs are unlocked in the presence of ATP via the formation of ATP-aptamer complexes, resulting in the release of the loads. As ATP is overexpressed in cancer cells, and since the AS1411 aptamer recognizes the nucleolin receptor sites on the cancer cell membrane, the doxorubicin-loaded NMOFs provide functional carriers for targeting and treatment of cancer cells. Preliminary cell experiments reveal impressive selective permeation of the NMOFs into MDA-MB-231 breast cancer cells as compared to MCF-10A normal epithelial breast cells. High cytotoxic efficacy and targeted drug release are observed with the ATP-AS1411-functionalized doxorubicin-loaded NMOFs.
机译：合成了由核酸结合链修饰的金属有机骨架（NMOF）组成的纳米粒子。 NMOF装载有荧光剂或抗癌药阿霉素，并且装载的NMOF通过与包含以笼型构型的ATP适体或ATP-AS1411杂交适体的互补核酸杂交而加帽。 NMOF在ATP存在下通过ATP-适体复合物的形成而被解锁，从而导致负载的释放。由于ATP在癌细胞中过表达，并且由于AS1411适体识别癌细胞膜上的核仁素受体位点，因此负载阿霉素的NMOF为癌细胞的靶向和治疗提供了功能性载体。初步的细胞实验显示，与MCF-10A正常上皮性乳腺癌细胞相比，NMOFs具有令人印象深刻的选择性渗透入MDA-MB-231乳腺癌细胞的能力。使用ATP-AS1411功能化的阿霉素加载的NMOF可以观察到高细胞毒性功效和靶向药物释放。

著录项

  • 来源
    《Advanced Functional Materials》 |2017年第37期|1702102.1-1702102.9|共9页
  • 作者

    Chen Wei-Hai; Yu Xu; Liao Wei-Ching; Sohn Yang Sung; Cecconello Alessandro; Kozell Anna; Nechushtai Rachel; Willner Itamar;

  • 作者单位

    Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, Inst Chem, IL-91904 Jerusalem, Israel;

    Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, Inst Chem, IL-91904 Jerusalem, Israel;

    Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, Inst Chem, IL-91904 Jerusalem, Israel;

    Hebrew Univ Jerusalem, Inst Life Sci, IL-91904 Jerusalem, Israel;

    Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, Inst Chem, IL-91904 Jerusalem, Israel;

    Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, Inst Chem, IL-91904 Jerusalem, Israel;

    Hebrew Univ Jerusalem, Inst Life Sci, IL-91904 Jerusalem, Israel;

    Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, Inst Chem, IL-91904 Jerusalem, Israel;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cytotoxicity; doxorubicin; drug release; nucleic acids; targeting;

    机译：细胞毒性;阿霉素;药物释放;核酸;靶向;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号