以三乙胺直接加入法制备金属-有机骨架MOF-5,采用X射线粉末衍射(XRD)、红外光谱(IR)和热重分析(TG)对所得样品进行表征.分别以辣椒素和5-氟尿嘧啶( 5-Fluouourail,5-FU)为模型药物,研究了MOF-5对2种药物的载药及体外释药性能.通过将所得样品的XRD和IR谱图与标准谱图比对确定了样品的结构.TG结果表明,所制备的MOF-5热稳定性良好.MOF-5对辣椒素的最高载入量达0.592 g/g载体,对5-FU的最高载入量为0.315 g/g载体,两种载药体系的体外释药均为明显的两相模式.体外细胞毒性实验结果表明,MOF-5具有良好的生物相容性.%Porous metal-organic frameworks(MOF-5) were synthesized and the structure of synthetic MOF-5 was confirmed by XRD and IR spectrum. According to the result of TG, the synthetic MOF-5 displayed better thermo-stabilization. The capsaicin or 5-fluouourail was loaded in synthetic MOF-5 and in vitro drug release profile were investigated, respectively. The highest drug loading rates are 0. 592 g/g MOF for capsaicin and 0. 315 g/g MOF for 5-FU in drug-loaded MOF-5, respectively. The in vitro drug release profile of both MOF-5 formulations showed a clear biphasic release pattern. Cytotoxicity test showed that MOF-5 displayed good bio-compatility.
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