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首页> 外文期刊>Langmuir: The ACS Journal of Surfaces and Colloids >DNA-Responsive SiO2 Nanoparticles, Metal-Organic Frameworks, and Microcapsules for Controlled Drug Release
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DNA-Responsive SiO2 Nanoparticles, Metal-Organic Frameworks, and Microcapsules for Controlled Drug Release

机译：DNA响应性SiO2纳米颗粒，金属有机框架和用于受控药物释放的微胶囊

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摘要

Recent advances addressing the development of stimuli-responsive nucleic acid (DNA)-functionalized micro/nanocarriers for the controlled release of drugs are presented. The DNA associated with the drug-loaded carriers acts as capping units that lock the drugs in the carriers. In the presence of appropriate triggers, the capping units are unlocked, resulting in the release of the drugs. Three types of DNA-modified carriers are discussed, including mesoporous SiO2 nanoparticles (MP SiO2 NPs), metal- organic framework nanoparticles (NMOFs) and micro/nanocapsules. The triggers to unlock the DNA gating units include pH, the dissociation of K+-stabilized G-quadruplexes in the presence of crown ethers, the catalytic dissociation of the capping units by enzymes or DNAzymes, the dissociation of capping units by the formation of aptamer-ligand complexes (particularly ligands acting as biomarkers for different diseases), and the use of light for the photochemical unlocking of the DNA gates. Different issues related to the targeting of the different drug-loaded carriers to cancer cells, the switchable ON/OFF release of the drug loads, and the selective cytotoxicity of the drug-loaded carriers toward cancer cells are discussed. Finally, the future perspectives of the stimuli-responsive DNA-based, drug-loaded micro/nanocarriers for future nanomedicine and, in particular, the development of autonomous sense-and-treat systems are addressed.
机译：最近的进展寻址刺激响应核酸（DNA） - 功能化的微/用于药物的控制释放的纳米载体呈现的发展。与药物负载载体相关的DNA充当覆盖载体中药物的封端单元。在适当的触发器存在下，封端单元被解锁，导致药物的释放。讨论了三种类型的DNA改性载体，包括中孔SiO 2纳米颗粒（MP SiO 2 NPS），金属 - 有机骨架纳米颗粒（NMOFS）和微/纳米胶囊。解锁DNA浇注单元的触发器包括pH，在冠醚存在下K + -Stabilized G-四边形的解离，封端单元通过酶或DNAzymes催化解离，通过形成适体的封端单元的解离 - 配体络合物（特别是配位体作为生物标志物用于不同的疾病），以及用于该DNA门的光化学解锁光的使用。讨论了与癌细胞对癌细胞的不同药物载体的靶向有关的不同问题，讨论了药物载荷的可切换开/关释放，以及药物负载载体对癌细胞的选择性细胞毒性。最后，对未来纳米医生的刺激响应性DNA的刺激性DNA的药物负载的微/纳米载体的未来观点是，特别是自主感觉和治疗系统的发展。

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