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首页> 外文期刊>Journal of Materials Engineering and Performance >Expression of TGF-β in Fractures Fixed by Nitinol Swan-like Memory Compressive Connectors
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Expression of TGF-β in Fractures Fixed by Nitinol Swan-like Memory Compressive Connectors

机译：TGF-β在镍钛诺天鹅样记忆压缩连接器固定的骨折中的表达

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摘要

In this article, the effect of internal fixation of a Nitinol swan-like memory compressive connector (SMC) on the temporal expression of transforming growth factor-β (TGF-β) at fracture sites is evaluated. Specimens were collected from 35 New Zealand rabbits modeled for bilateral humeral fracture fixed with either SMC or stainless dynamic compression plate (DCP). Five rabbits each were killed at day 1, 3, 7, 14, 21, 28, and 56. The local positive staining potency, positive area ratio, and positive index of TGF-β were measured using an immunohistochemistry approach (EnVision) in combination with a computerized image analysis system. TGF-β staining was seen in mesenchymal cells, osteoblasts, chondrocytes, and in the extracellular matrix of fractures fixed in both the SMC and the DCP samples without a significant difference in staining at both the early stages (days 1 and 3) and day 56. A higher TGF-β content was observed in the fractures fixed with SMC when compared to that of DCP from day 7 to 28. As a conclusion, TGF-β is highly expressed in fractures fixed with SMC during chondrogenesis stage and entochondrostosis stage. Finally, the mechanism of how SMC promoting synthesis and secretion of TGF-β in the process of fracture healing has been discussed.
机译：在本文中，评估了镍钛诺天鹅样记忆压缩连接器（SMC）的内部固定对骨折部位转化生长因子-β（TGF-β）的时间表达的影响。从35只新西兰兔中收集标本，以SMC或不锈钢动态加压板（DCP）固定双侧肱骨骨折。在第1、3、7、14、21、28和56天分别处死5只兔子。结合免疫组织化学方法（EnVision）测量局部阳性染色力，阳性面积比和TGF-β阳性指数计算机图像分析系统。在间充质细胞，成骨细胞，软骨细胞和固定在SMC和DCP样品中的骨折的细胞外基质中均观察到TGF-β染色，在早期（第1天和第3天）和第56天染色均无显着差异从第7天到第28天，与DCP相比，SMC固定的骨折中TGF-β含量更高，因此，在软骨形成阶段和软骨内融合阶段，TGF-β在SMC固定的骨折中高表达。最后，探讨了SMC在骨折愈合过程中如何促进TGF-β合成和分泌的机制。

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