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首页> 外文会议>International Conference on Shape Memory and Superelastic Technologies >Expression of TGF-beta in Fractures Fixed-by Nitinol Swan-like Memory Compresslve Connectors
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Expression of TGF-beta in Fractures Fixed-by Nitinol Swan-like Memory Compresslve Connectors

机译：用Nitinol Sk样内存压缩连接器的骨折中TGF-β在骨折中的表达

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摘要

In this article, the effect of internal fixation of a Nitinol swan-like memory compressive connector (SMC) on the temporal expression of transforming growth factor-p (TGF-P) at fracture sites is evaluated. Specimens were collected from 35 New Zealand rabbits modeled for bilateral humeral fracture fixed with either SMC or stainless dynamic compression plate (DCP). Five rabbits each were killed at day 1, 3, 7, 14, 21, 28, and 56. The local positive staining potency, positive area ratio, and positive index of TGF-P were measured using an immunohistochemistry approach (EnVision) in combination with a computerized image analysis system. TGF-P staining was seen in mesenchymal cells, osteoblasts, chondrocytes, and in the extracellular matrix of fractures fixed in both the SMC and the DCP samples without a significant difference in staining at both the early stages (days 1 and 3) and day 56. A higher TGF-P content was observed in the fractures fixed with SMC when compared to that of DCP from day 7 to 28. As a conclusion, TGF-P is highly expressed in fractures fixed with SMC during chondrogenesis stage and entochondrostosis stage. Finally, the mechanism of how SMC promoting synthesis and secretion of TGF-P in the process of fracture healing has been discussed.
机译：在本文中，评估硝基甘油天鹅样记忆压缩连接器（SMC）对骨折位点处转化生长因子-P（TGF-P）的时间表达的效果。从35种新西兰兔子收集标本，该兔子为双侧肱骨骨折，用SMC或不锈动态压缩板（DCP）为固定。每天在第1,3,7,14,21,21,28和56天中杀死了五只兔子。使用免疫组化方法（Envision）组合测量TGF-P的局部正染色效力，阳性面积比和正指数使用计算机化图像分析系统。在间充质细胞，成骨细胞，软骨细胞中观察到TGF-P染色，以及在SMC和DCP样品中固定在SMC和DCP样品中的细胞外基质中，在早期阶段（第1天和第3天）和第56天的染色中没有显着差异。与SMC的骨折中观察到较高的TGF-P含量，与DCP从第7天至28的DCP相比。作为结论，TGF-P在软骨发生阶段和患者症期间用SMC固定的裂缝中高度表达。最后，已经讨论了SMC如何在骨折愈合过程中促进TGF-P的合成和分泌的机制。

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