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Glucomannan asymmetric membranes for wound dressing

机译：葡甘露聚糖不对称膜用于伤口敷料

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摘要

Asymmetric membranes present promising characteristics for wound dressing applications. A porous structure uptakes the wound exudate, whereas an occlusive layer (upper film) inhibits the microbial penetration and prevents an excessive loss of water. Konjac glucomannan (KGM) is a natural polysaccharide that has been investigated as wound dressings in the form of films, sponges, and hydrogels due to its flexibility, swelling capacity, biocompatibility, and low cost. However, there are no studies on literature regarding the development of KGM asymmetric membranes. In this study, we investigated a new casting-freezing process for the production of KGM asymmetric membranes. The scanning electron microscopy and thermogravimetric analyses indicated an asymmetric morphology and a good thermal stability of the membrane samples, respectively. Moreover, biological, mechanical, and fluid-handling capacity tests showed that the membrane is biocompatible and resistant to handling structure, which was also able to retain the ideal moist conditions for wound healing.
机译：不对称膜为伤口敷料应用提供了令人鼓舞的特性。多孔结构吸收伤口渗出液，而阻塞层（上层膜）则抑制微生物的渗透并防止水分过多流失。魔芋葡甘露聚糖（KGM）是一种天然多糖，由于其柔韧性，溶胀能力，生物相容性和低成本而被研究为薄膜，海绵和水凝胶形式的伤口敷料。但是，关于KGM不对称膜的发展，没有文献研究。在这项研究中，我们研究了一种用于生产KGM不对称膜的新型浇铸冷冻工艺。扫描电子显微镜和热重分析表明膜样品分别具有不对称的形态和良好的热稳定性。此外，生物学，机械和流体处理能力测试表明，该膜具有生物相容性，并能抵抗处理结构，该膜还能够保留理想的湿润条件以用于伤口愈合。

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  • 来源
    《Journal of Materials Research》 |2019年第4期|481-489|共9页
  • 作者

    Genevro Giovana Maria; Gomes Neto Reginaldo Jose; Beppu Marisa Nlasumi; de Moraes Mariana Agostini; Paulo Leticia de Almeida; Lopes Patricia Santos;

  • 作者单位

    Univ Estadual Campinas, Sch Chem Engn, Dept Mat & Bioproc Engn, BR-13083852 Campinas, SP, Brazil;

    Univ Estadual Campinas, Sch Chem Engn, Dept Mat & Bioproc Engn, BR-13083852 Campinas, SP, Brazil;

    Univ Estadual Campinas, Sch Chem Engn, Dept Mat & Bioproc Engn, BR-13083852 Campinas, SP, Brazil;

    Univ Fed Sao Paulo, Environm Chem & Pharmaceut Sci Inst, Dept Chem Engn, BR-09913030 Diadema, SP, Brazil;

    Univ Fed Sao Paulo, Dept Pharmaceut Sci, Environm Chem & Pharmaceut Sci Inst, BR-09913030 Diadema, SP, Brazil;

    Univ Fed Sao Paulo, Dept Pharmaceut Sci, Environm Chem & Pharmaceut Sci Inst, BR-09913030 Diadema, SP, Brazil;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    polymers; film; porosity;

    机译：聚合物;薄膜;孔隙率;

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