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首页> 外文期刊>Journal of Materials Research >Evaluation and validation of synergistic effects of amyloid-beta inhibitor-gold nanoparticles complex on Alzheimer's disease using deep neural network approach
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Evaluation and validation of synergistic effects of amyloid-beta inhibitor-gold nanoparticles complex on Alzheimer's disease using deep neural network approach

机译：使用深度神经网络方法评估和评估淀粉样蛋白-β抑制剂-金纳米颗粒复合物对阿尔茨海默氏病的协同作用

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摘要

Numerous studies have reported that amyloid-beta 42 (A beta-42) protein is a high-profile risk factor associated with the onset and progression of Alzheimer's disease (AD). Accumulation of extracellular senile plaques, synaptic degeneration, and intracellular neurofibrillary tangles were recorded as essential features that facilitate the onset of A beta-42, resulting in AD. Hence, we attempted a new screening technique to discover potential inhibitors against A beta-42 using an in silico deep neural network approach. We screened PubChem compounds library and found wgx-50 as a potential inhibitor of A beta-42. Also, synergistic effects of wgx-50-gold nanoparticles (AuNPs) complex induced significant inhibition of A beta-42, compared with those of wgx-50 alone. Further, molecular docking analysis, systems biology approach, and time course simulation confirmed that synergistic effects of wgx-50-AuNPs complex have potential application in the treatment for AD. Additionally, we proposed the biological circuit for AD induced by A beta-42 that can be used to monitor the effect of drugs on AD.
机译：大量研究报告称，β-淀粉样蛋白42（Aβ-42）蛋白是与阿尔茨海默氏病（AD）发病和进展相关的高风险因素。胞外老年斑的积累，突触变性和胞内神经原纤维缠结被记录为促进A beta-42发作，导致AD的基本特征。因此，我们尝试了一种新的筛选技术，使用计算机深度神经网络方法来发现针对A beta-42的潜在抑制剂。我们筛选了PubChem化合物库，并发现wgx-50作为A beta-42的潜在抑制剂。此外，与单独使用wgx-50相比，wgx-50-金纳米颗粒（AuNPs）复合物的协同作用可显着抑制A beta-42。此外，分子对接分析，系统生物学方法和时程模拟证实，wgx-50-AuNPs复合物的协同作用在治疗AD中具有潜在的应用。此外，我们提出了由A beta-42诱导的AD的生物回路，可用于监测药物对AD的作用。

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  • 来源
    《Journal of Materials Research》 |2019年第11期|1845-1853|共9页
  • 作者

    Kaushik Arran Chandra; Kumar Ajay; Deng Zhennan; Khan Abbas; Junaid Muhammad; Ali Arif; Bharadwaj Shiv; Wei Dong-Qing;

  • 作者单位

    Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China|Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China;

    Natl Sun Yat Sen Univ, Dept Mech & Electromech Engn, Kaohsiung 804, Taiwan;

    Lanzhou Univ, Coll Life Sci, Lanzhou 730000, Gansu, Peoples R China;

    Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China|Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China;

    Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China|Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China;

    Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China|Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China;

    Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey;

    Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China|Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Alzheimer's disease; amyloid-beta 42; AuNP; biochemical pathway;

    机译：阿尔茨海默病;淀粉样β42;AuNP;生化途径;

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