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首页> 外文期刊>Journal of Materials Research >Evaluation and validation of synergistic effects of amyloid-beta inhibitor-gold nanoparticles complex on Alzheimer's disease using deep neural network approach
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Evaluation and validation of synergistic effects of amyloid-beta inhibitor-gold nanoparticles complex on Alzheimer's disease using deep neural network approach

机译：利用深神经网络方法评价和验证淀粉样蛋白β抑制剂 - 金纳米粒子复合物对阿尔茨海默病的协同作用

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摘要

Numerous studies have reported that amyloid-beta 42 (A beta-42) protein is a high-profile risk factor associated with the onset and progression of Alzheimer's disease (AD). Accumulation of extracellular senile plaques, synaptic degeneration, and intracellular neurofibrillary tangles were recorded as essential features that facilitate the onset of A beta-42, resulting in AD. Hence, we attempted a new screening technique to discover potential inhibitors against A beta-42 using an in silico deep neural network approach. We screened PubChem compounds library and found wgx-50 as a potential inhibitor of A beta-42. Also, synergistic effects of wgx-50-gold nanoparticles (AuNPs) complex induced significant inhibition of A beta-42, compared with those of wgx-50 alone. Further, molecular docking analysis, systems biology approach, and time course simulation confirmed that synergistic effects of wgx-50-AuNPs complex have potential application in the treatment for AD. Additionally, we proposed the biological circuit for AD induced by A beta-42 that can be used to monitor the effect of drugs on AD.
机译：据报道，许多研究报道了淀粉样蛋白-β22（β-42）蛋白是与阿尔茨海默病（AD）的发作和进展相关的高型风险因子。细胞外老年斑块，突触变性和细胞内神经纤维缠结的积累被记录为促进β-42发作的基本特征，导致广告。因此，我们尝试了一种新的筛选技术，使用Silico深神经网络方法使用硅对抗β-42来发现潜在的抑制剂。我们筛选了Pubchem化合物文库，并发现WGX-50作为β-42的潜在抑制剂。此外，与单独的WGX-50相比，WGX-50-金纳米颗粒（AUNP）复合物（AUNP）复合物的协同作用诱导β-42的显着抑制。此外，分子对接分析，系统生物学方法和时间课程模拟证实，WGX-50-AUNPS复合物的协同效应具有潜在的应用在AD的治疗中。另外，我们提出了通过β-42诱导的AD的生物回路，其可用于监测药物对广告的影响。

著录项

  • 来源
    《Journal of Materials Research》 |2019年第11期|1845-1853|共9页
  • 作者

    Kaushik Arran Chandra; Kumar Ajay; Deng Zhennan; Khan Abbas; Junaid Muhammad; Ali Arif; Bharadwaj Shiv; Wei Dong-Qing;

  • 作者单位

    Shanghai Jiao Tong Univ State Key Lab Microbial Metab Shanghai 200240 Peoples R China|Shanghai Jiao Tong Univ Sch Life Sci & Biotechnol Shanghai 200240 Peoples R China;

    Natl Sun Yat Sen Univ Dept Mech & Electromech Engn Kaohsiung 804 Taiwan;

    Lanzhou Univ Coll Life Sci Lanzhou 730000 Gansu Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Microbial Metab Shanghai 200240 Peoples R China|Shanghai Jiao Tong Univ Sch Life Sci & Biotechnol Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Microbial Metab Shanghai 200240 Peoples R China|Shanghai Jiao Tong Univ Sch Life Sci & Biotechnol Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Microbial Metab Shanghai 200240 Peoples R China|Shanghai Jiao Tong Univ Sch Life Sci & Biotechnol Shanghai 200240 Peoples R China;

    Sabanci Univ Nanotechnol Res & Applicat Ctr TR-34956 Istanbul Turkey;

    Shanghai Jiao Tong Univ State Key Lab Microbial Metab Shanghai 200240 Peoples R China|Shanghai Jiao Tong Univ Sch Life Sci & Biotechnol Shanghai 200240 Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Alzheimer's disease; amyloid-beta 42; AuNP; biochemical pathway;

    机译：阿尔茨海默病;淀粉样蛋白β22;aunp;生化途径;

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