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首页> 外文期刊>Journal of Materials Research >Fabrication of polyelectrolyte microspheres using porous manganese carbonate as sacrificial template for drug delivery application
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Fabrication of polyelectrolyte microspheres using porous manganese carbonate as sacrificial template for drug delivery application

机译：以多孔碳酸锰为牺牲模板的聚电解质微球的制备

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摘要

This paper describes the fabrication of polyelectrolyte microspheres using porous manganese carbonate as a sacrificial template for entrapped photosensitizer (PS) drugs for photodynamic therapy application. These particles were used as templates for polyelectrolyte layer-by-layer assembly (Lbl) of two oppositely charged polyelectrolytes: poly(styrene sulfonate) and poly(allylamine hydrochloride). When the polyelectrolyte multilayer shell was built around the MnCO3 core by the Lbl protocol and the core was extracted with acid solution and EDTA, the resultant assembly consisted of hollow polyelectrolyte spheres. Chloroaluminum phthalocyanine was chosen as the model drug to load into the hollow spheres. All the spectroscopic results presented showed excellent photophysical parameters of the studied drug. The fabrication of polyelectrolyte hollow spheres can be used as an optimal medium for a variety of bioactive materials, which can also be encapsulated by the proposed method.
机译：本文介绍了使用多孔碳酸锰作为捕获模板的包埋光敏剂（PS）药物在光动力疗法中的应用，制备聚电解质微球的方法。这些颗粒用作两种带相反电荷的聚电解质（聚（苯乙烯磺酸盐）和聚（烯丙胺盐酸盐））的聚电解质逐层组装（Lbl）的模板。当通过Lbl协议在MnCO3核芯周围构建聚电解质多层壳并用酸溶液和EDTA萃取核芯时，所得组件由空心聚电解质球组成。选择氯铝酞菁作为模型药物以加载到空心球中。呈现的所有光谱结果均显示了所研究药物的优异光物理参数。聚电解质空心球的制备可用作各种生物活性材料的最佳介质，该生物活性材料也可通过提出的方法进行封装。

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