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Glucose-responsive shape-memory cryogels

机译：葡萄糖响应形状 - 记忆冷冻机

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摘要

Boronic ester bonds can be reversibly formed between phenylboronic acid (PBA) and triol moieties. Here, we aim at a glucose-induced shape-memory effect by implementing such bonds as temporary netpoints, which are cleavable by glucose and by minimizing the volume change upon stimulation by a porous cryogel structure. The polymer system consisted of a semi-interpenetrating network (semi-IPN) architecture, in which the triol moieties were part of the permanent network and the PBA moieties were located in the linear polymer diffused into the semi-IPN. In an alkaline medium (pH = 10), the swelling ratio was approximately 35, independent of C_(glu) varied between 0 and 300 mg/dL. In bending experiments, shape fixity R_f ≈ 80% and shape recovery R_r ≈ 100% from five programming/recovery cycles could be determined. R_f was a function of C_(gle) in the range from 0 to 300 mg/ dL, which accords with the fluctuation range of C_(glu) in human blood. In this way, the shape-memory hydrogels could play a role in future diabetes treatment options.
机译：硼酸酯键可以在苯硼酸（PBA）和三醇部分之间可逆地形成。这里，我们通过将这种键作为临时网点实施，其旨在通过葡萄糖切割并通过多孔冷磁凝胶结构刺激以最小化体积变化来实现葡萄糖诱导的形状记忆效果。聚合物系统由半互穿网络（半IPN）结构组成，其中三醇部分是永久网络的一部分，PBA部分位于扩散到半IPN中的线性聚合物中。在碱性介质（pH = 10）中，溶胀比约为35，与0至300mg / dL之间的C_（glu）无差。在弯曲实验中，形状固定性R_F≈80％和形状恢复R_R≈10％从五个编程/恢复循环中确定。 R_F是C_（GLE）的函数，其范围为0至300 mg / dL，其符合人血液中C_（glu）的波动范围。通过这种方式，形状记忆水凝胶可以在未来的糖尿病治疗方案中发挥作用。

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  • 来源
    《Journal of Materials Research》 |2020年第18期|2396-2404|共9页
  • 作者

    Marc Behl; Qian Zhao; Andreas Lendlein;

  • 作者单位

    Institute of Biomaterial Science Helmholtz-Zentrum Geesthacht Teltow 14513 Germany Tianjin University - Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine Teltow 14513 Germany;

    Institute of Biomaterial Science Helmholtz-Zentrum Geesthacht Teltow 14513 Germany Tianjin University - Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine Teltow 14513 Germany;

    Institute of Biomaterial Science Helmholtz-Zentrum Geesthacht Teltow 14513 Germany Tianjin University - Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine Teltow 14513 Germany Institute of Chemistry University of Potsdam Potsdam 14476 Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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