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Revealing the nanoindentation response of a single cell using a 3D structural finite element model

机译：使用3D结构有限元模型揭示单个电池的纳米凸缘响应

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摘要

Changes in the apparent moduli of cells have been reported to correlate with cell abnormalities and disease. Indentation is commonly used to measure these moduli; however, there is evidence to suggest that the indentation protocol employed affects the measured moduli, which can affect our understanding of how physiological conditions regulate cell mechanics. Most studies treat the cell as a homogeneous material or a simple core-shell structure consisting of cytoplasm and a nucleus: both are far from the real structure of cells. To study indentation protocol-dependent cell mechanics, a finite element model of key intracellular components (cortex layer, cytoplasm, actin stress fibres, microtubules, and nucleus) has instead been developed. Results have shown that the apparent moduli obtained with conical indenters decreased with increasing cone angle; however, this change was less significant for spherical indenters of increasing radii. Furthermore, the interplay between indenter geometry and intracellular components has also been studied, which is useful for understanding structure-mechanics-function relationships of cells.
机译：据报道，细胞表观模量的变化与细胞异常和疾病相关。压痕通常用于测量这些模量;然而，有证据表明，所用的压痕协议会影响测量的模数，这可能影响我们对生理条件如何调节细胞机制的理解。大多数研究将电池视为均匀材料或由细胞质和核组成的简单核壳结构：两者远离细胞的真实结构。为了研究缩进协议依赖性细胞力学，已经开发出键细胞内部件（皮质层，细胞质，肌动蛋白应激纤维，微管和核）的有限元模型。结果表明，随着锥形角度的增加，用锥形压痕获得的表观模量减少;然而，对于增加半径的球形压痕，这种变化不太重要。此外，还研究了压痕几何和细胞内部件之间的相互作用，这对于理解细胞的结构力函数关系是有用的。

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  • 来源
    《Journal of Materials Research》 |2021年第12期|2591-2600|共10页
  • 作者

    Wenjian Yang; Damien Lacroix; Lay Poh Tan; Jinju Chen;

  • 作者单位

    School of Engineering Newcastle University Stephenson Building Newcastle upon Tyne NE1 7RU UK;

    Department of Mechanical Engineering The University of Sheffield Pam Liversidge Mappin Street Sheffield S1 3JD UK;

    School of Materials Science & Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore;

    School of Engineering Newcastle University Stephenson Building Newcastle upon Tyne NE1 7RU UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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  • 正文语种 eng
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