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首页> 外文期刊>Journal of Materials Research >A targeted drug delivery system based on carbon nanotubes loaded with lobaplatin toward liver cancer cells
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A targeted drug delivery system based on carbon nanotubes loaded with lobaplatin toward liver cancer cells

机译：基于负载洛巴铂的碳纳米管靶向肝癌细胞的药物递送系统

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摘要

To eliminate the toxic effect of chemotherapy drug of lobaplatin (LBP) on body tissue in liver cancer therapy, this work prepared a nanodrug carrier based on polyethylene glycol-modified carbon nanotubes (PEG-CNTs) and then constructed a targeted drug delivery system (LBP-PEG-CNTs) by loading LBP on PEG-CNTs. Fluorescein isothiocyanate (FITC) was used to label PEG-CNTs to observe the cellular uptake of PEG-CNTs. In addition, the inhibitions of LBP-PEG-CNTs on HepG(2) cells were investigated. The results show that the FITC-labeled PEG-CNTs have good cell penetrability; meanwhile, LBP-PEG-CNTs have good stability, pH-controlled release property, and high inhibition rate on HepG(2) cells. To be specific, 80% of LBP is released under physiological conditions of liver cancer cells at pH 5.0, and LBP-PEG-CNTs show a high inhibition rate of 77.86% on HepG(2) cells, demonstrating that they have targeted, pH-controlled release and inhibition properties on HepG(2) cells.
机译：为了消除洛铂（LBP）化疗药物对肝癌人体组织的毒性作用，这项工作制备了一种基于聚乙二醇修饰的碳纳米管（PEG-CNT）的纳米药物载体，然后构建了靶向药物递送系统（LBP） -PEG-CNT）。异硫氰酸荧光素（FITC）用于标记PEG-CNT，以观察PEG-CNT的细胞摄取。此外，研究了LBP-PEG-CNTs对HepG（2）细胞的抑制作用。结果表明，FITC标记的PEG-CNT具有良好的细胞穿透性。同时，LBP-PEG-CNTs具有良好的稳定性，pH控释特性和对HepG（2）细胞的高抑制率。具体而言，在肝癌细胞的pH 5.0的生理条件下释放了80％的LBP，LBP-PEG-CNT对HepG（2）细胞显示出77.86％的高抑制率，表明它们具有针对性的pH-对HepG（2）细胞的控制释放和抑制特性。

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  • 来源
    《Journal of Materials Research》 |2018年第17期|2565-2575|共11页
  • 作者

    Yu Shiping; Li Qiang; Wang Junli; Du Jinglei; Gao Yuduan; Zhang Li; Chen Lin; Yang Yongzhen; Liu Xuguang;

  • 作者单位

    Shanxi Med Univ, Hosp 2, Intervent Treatment Dept, Taiyuan 030001, Shanxi, Peoples R China;

    Shanxi Med Univ, Hosp 2, Intervent Treatment Dept, Taiyuan 030001, Shanxi, Peoples R China;

    Taiyuan Univ Technol, Minist Educ, Key Lab Interface Sci & Engn Adv Mat, Taiyuan 030024, Shanxi, Peoples R China;

    Shanxi Med Univ, Hosp 2, Intervent Treatment Dept, Taiyuan 030001, Shanxi, Peoples R China;

    Shanxi Dayi Hosp, Ophthalmol Dept, Taiyuan 030032, Shanxi, Peoples R China;

    Shanxi Dayi Hosp, Urol Dept, Taiyuan 030032, Shanxi, Peoples R China;

    Taiyuan Univ Technol, Minist Educ, Key Lab Interface Sci & Engn Adv Mat, Taiyuan 030024, Shanxi, Peoples R China;

    Taiyuan Univ Technol, Minist Educ, Key Lab Interface Sci & Engn Adv Mat, Taiyuan 030024, Shanxi, Peoples R China;

    Taiyuan Univ Technol, Minist Educ, Key Lab Interface Sci & Engn Adv Mat, Taiyuan 030024, Shanxi, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    carbon nanotubes; lobaplatin; liver cancer cell; anticancer; target;

    机译：碳纳米管;叶铂;肝癌细胞;抗癌;靶标;

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