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首页> 外文期刊>Journal of Materials Research >Effects of poly(para-dioxanone-co-L-lactide) on the in vitro hydrolytic degradation behaviors of poly(L-lactide)/poly(para-dioxanone) blends
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Effects of poly(para-dioxanone-co-L-lactide) on the in vitro hydrolytic degradation behaviors of poly(L-lactide)/poly(para-dioxanone) blends

机译：聚（对二恶烷酮-co-L-丙交酯）对聚（L-丙交酯）/聚（对二恶烷酮）共混物体外水解降解行为的影响

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摘要

Poly(L-lactide)/poly(para-dioxanone) (PLLA/PPDO) (85/15 w/w) blends with 0, 1, 3, and 5 wt% poly(para-dioxanone-co-L-lactide) (PDOLLA) as a compatibilizer were prepared by solution coprecipitation. The in vitro hydrolytic degradation (HD) of blend bars with different contents of PDOLLA was studied by immersing the bars in a phosphate buffer solution (PBS) at pH 7.49. To estimate the degradation of blend bars, the weight loss, water absorption, thermal properties, surface morphology, and mechanical properties of blend bars, as well as the pH value changes of the PBS, were studied for 8 wk of HD. By adding 1 and 3 wt% PDOLLA, the weight loss of PLLA/PPDO (85/15 w/w) blends increased from 6.4 to 6.8 and 7.4% after 8 wk of HD, 6.2 and 15.6% increment, respectively, while, the average tensile strength of PLLA/PPDO (85/15 w/w) blends for 2-8 wk of HD increased from 25.8 to 29.0 MPa and 31.0 MPa, 12.4 and 20.2% increment, respectively. Considering their good mechanical properties and HD rate, the PLLA/PPDO (85/15 w/w) blends with 1 and 3 wt% PDOLLA are potential to be used as a medical implant material.
机译：聚（L-丙交酯）/聚（对二恶烷酮）（PLLA / PPDO）（85/15 w / w）与0、1、3和5 wt％聚（对二恶烷酮-co-L-丙交酯）的混合物（PDOLLA）作为增容剂通过溶液共沉淀制备。通过将皂条浸入pH 7.49的磷酸盐缓冲溶液（PBS）中，研究了具有不同PDOLLA含量的皂条的体外水解降解（HD）。为了评估混合棒的降解情况，研究了8 wk HD时混合棒的重量损失，吸水率，热性能，表面形态和机械性能，以及PBS的pH值变化。通过添加1和3 wt％的PDOLLA，HD每周8周后，PLLA / PPDO共混物（85/15 w / w）的重量损失从6.4增加到6.8和7.4％，分别增加6.2和15.6％。 2-8 wk HD的PLLA / PPDO（85/15 w / w）共混物的平均抗张强度分别从25.8 MPa增加到29.0 MPa和31.0 MPa，分别增加了12.4和20.2％。考虑到它们良好的机械性能和HD率，将PLLA / PPDO（85/15 w / w）与1％和3％（重量）的PDOLLA混合可以用作医疗植入材料。

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  • 来源
    《Journal of Materials Research》 |2015年第6期|860-868|共9页
  • 作者

    Xulong Xie; Wei Bai; Congming Tang; Dongliang Chen; Chengdong Xiong;

  • 作者单位

    Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China and University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;

    Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041,People's Republic of China;

    Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637009, People's Republic of China;

    Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041,People's Republic of China;

    Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041,People's Republic of China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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