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首页> 外文期刊>Journal of Materials Research >Controlled loading of paramagnetic gadolinium oxide nanoplates in PMAO-g-PEG as effective T_1-weighted MRI contrast agents
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Controlled loading of paramagnetic gadolinium oxide nanoplates in PMAO-g-PEG as effective T_1-weighted MRI contrast agents

机译：顺磁性氧化g纳米板作为有效的T_1加权MRI造影剂在PMAO-g-PEG中的受控加载

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摘要

Plate-shaped Gd_2O_3 nanoclusters (GNCs) with well-controlled loading were fabricated by using amphiphilic poly(maleic anhydride-alt-1-octadecene) (PMAO) grafted with PEG as nanogel. The hydrodynamic size of the obtained GNCs was well controlled to ＜260 nm under appropriate emulsion process conditions and they showed excellent long-term dispersibility in phosphate buffer saline. MRI measurements clearly indicated the substantial improvement in T_1 effect of the nanoclusters as compared with the individual Gd_2O_3 nanoplates. The obtained GNCs possessed a high r_1 value of 7.948 s~(-1) mM~(-1) [Gd], which is 2.23 times higher than that of the commercial product Gd-DOTA, and low r_2/r_1 of 1.04. In vitro test of the obtained GNCs was demonstrated in NIH/3T3 cell lines, and clear T_1-weighted images were obtained. Thus, the PMAO-g-PEG assisted GNCs were potentially useful for T_1-weighted MRI contrast agents.
机译：以两亲聚乙二醇的两亲性聚（马来酸酐-alt-1-十八烯）（PMAO）为载体，制备了具有良好载量的板状Gd_2O_3纳米团簇。在适当的乳化工艺条件下，所获得的GNC的流体动力学尺寸可以很好地控制在＜260 nm，并且它们在磷酸盐缓冲液中显示出优异的长期分散性。 MRI测量清楚地表明，与单个Gd_2O_3纳米板相比，纳米团簇的T_1效应有了实质性的改善。获得的GNC具有7.948 s〜（-1）mM〜（-1）[Gd]的高r_1值，是商业产品Gd-DOTA的r_1值的2.23倍，而低r_2 / r_1为1.04。在NIH / 3T3细胞系中证明了获得的GNC的体外测试，并获得了清晰的T_1加权图像。因此，PMAO-g-PEG辅助的GNC对T_1加权MRI造影剂可能有用。

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  • 来源
    《Journal of Materials Research》 |2014年第15期|1626-1634|共9页
  • 作者

    Jiaquan Yuan; Erwin Peng; Jun Min Xue;

  • 作者单位

    Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore (NUS), Singapore 117574, Singapore;

    Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore (NUS), Singapore 117574, Singapore;

    Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore (NUS), Singapore 117574, Singapore;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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