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首页> 外文期刊>Journal of Materials Research >The role of alternating current electric field for cell adhesion on 2D and 3D biomimetic scaffolds based on polymer materials and adhesive proteins
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The role of alternating current electric field for cell adhesion on 2D and 3D biomimetic scaffolds based on polymer materials and adhesive proteins

机译：交流电场对基于高分子材料和粘附蛋白的2D和3D仿生支架上细胞粘附的作用

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摘要

Tissue engineering principles suggest the formation of 3D scaffolds based on polymer fibers and adhesive proteins. These scaffolds aim to mimic the native extracellular matrix and thus providing a favorable environment for cell attachment and proliferation. The application of an electric field (EF) can influence the quantity and the spatial orientation/conformation of adsorbed proteins, which could lead to changes in their functions. We study the influence of alternating current (AC) EF on the adsorption of fibronectin onto poly(etherimide) (PEI) electrospun fiber materials in 3D structures and subsequent cell adhesion. The results are compared with 2D PEI material and glass surface. 3D scaffolds adsorbed a lower amount of fibronectin than 2D film or glass. Application of AC EF with a frequency of 1 Hz decreased the adsorption of fibronectin. Cell adhesion on 3D materials was reduced compared with 2D film and glass. The application of EF with frequencies between 1 and 10 Hz improved cell adhesion on both 2D and 3D materials.
机译：组织工程原理建议基于聚合物纤维和粘附蛋白的3D支架的形成。这些支架旨在模拟天然细胞外基质，从而为细胞附着和增殖提供有利的环境。电场（EF）的施加会影响吸附蛋白的数量和空间取向/构象，这可能导致其功能发生变化。我们研究了交流电（AC）EF对纤连蛋白在3D结构中的聚醚酰亚胺（PEI）电纺纤维材料上的吸附以及随后细胞粘附的影响。将结果与2D PEI材料和玻璃表面进行比较。与2D薄膜或玻璃相比，3D支架吸附的纤连蛋白含量更低。使用频率为1 Hz的AC EF会降低纤连蛋白的吸附。与2D薄膜和玻璃相比，在3D材料上的细胞粘附性降低。频率在1到10 Hz之间的EF的应用改善了2D和3D材料上的细胞粘附。

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  • 来源
    《Journal of Materials Research》 |2013年第16期|2180-2186|共7页
  • 作者

    V. Pehlivanova; V. Krasteva; B. Seifert; K. Luetzow; I. Tsoneva; T. Becker; K. Richau; A. Lendlein; R. Tzoneva;

  • 作者单位

    Department ' Electroinduced and adhesive properties', Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria;

    Department ' Electroinduced and adhesive properties', Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria;

    Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Teltow 14513, Germany;

    Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Teltow 14513, Germany;

    Department 'Electroinduced and adhesive properties', Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria;

    Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Teltow 14513, Germany;

    Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Teltow 14513, Germany;

    Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Teltow 14513, Germany;

    Department 'Electroinduced and adhesive properties', Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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