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首页> 外文期刊>Journal of Materials Research >Bioinspired Synthesis Of Self-assembled Calcium Phosphate Nanocomposites Using Block Copolymer-peptide Conjugates
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Bioinspired Synthesis Of Self-assembled Calcium Phosphate Nanocomposites Using Block Copolymer-peptide Conjugates

机译：使用嵌段共聚物-肽共轭物的生物启发合成自组装磷酸钙纳米复合材料

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摘要

Thermoreversibly gelling block copolymers conjugated to hydroxyapatite-nucleating peptides were used to template the growth of inorganic calcium phosphate in aqueous solutions. Nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR), transmission electron microscopy, x-ray diffraction, and small-angle scattering were used to characterize these samples and confirm that the peptides promoted the growth of hydroxyapatite as the inorganic phase. Three different polymer templates were used with varying charges on the polymer chains (nonionic, anionic, and zwitterionic), to investigate the role of charge on mineralization. All of the polymer-inorganic solutions exhibited thermoreversible gelation above room temperature. Nanocomposite formation was confirmed by solid-state NMR, and several methods identified the inorganic component as hydroxyapatite. Small angle x-ray scattering and electron microscopy showed thin, elongated crystallites. Thermogravimetric analysis showed an inorganic content of 30-45 wt% (based on the mass of the dried gel at ～200 ℃) in the various samples. Our work offers routes for bioinspired bottom-up approaches for the development of novel, self-assembling, injectable nanocomposite biomaterials for potential orthopedic applications.
机译：与羟基磷灰石成核肽偶联的热可逆胶凝嵌段共聚物用于模板化无机磷酸钙在水溶液中的生长。核磁共振（NMR），傅立叶变换红外（FTIR），透射电子显微镜，x射线衍射和小角散射被用来表征这些样品，并证实这些肽促进了作为无机相的羟基磷灰石的生长。使用三种不同的聚合物模板，在聚合物链上具有不同的电荷（非离子，阴离子和两性离子），以研究电荷对矿化的作用。所有的聚合物-无机溶液在室温以上均表现出热可逆凝胶化。通过固态NMR确认了纳米复合物的形成，并且几种方法将无机组分鉴定为羟基磷灰石。小角X射线散射和电子显微镜显示出细长的微晶。热重分析表明，各种样品中的无机含量为30-45 wt％（基于〜200℃干燥凝胶的质量）。我们的工作为生物启发性的自下而上方法提供了途径，从而为潜在的骨科应用开发了新型，自组装，可注射的纳米复合生物材料。

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