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首页> 外文期刊>Journal of materials science >Design and in vitro evaluation of transdermal patches based on ibuprofen-loaded electrospun fiber mats
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Design and in vitro evaluation of transdermal patches based on ibuprofen-loaded electrospun fiber mats

机译：基于布洛芬的电纺纤维垫的透皮贴剂的设计和体外评估

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摘要

To improve the poor compatibility among different components of Drug-in-adhesive type patch, two novel plasters (Drug-in-fiber and Drug-in-adhesive/fiber) were developed based on ibuprofen (IBU)-loaded fiber mats. These fibrous mats were fabricated via electrospin-ning of cellulose acetate/poly(vinylpyrrolidone) composites in a binary solvent of N,N-dimethyl acetamide/acetone. Physical status studies suggested that Drug-in-fiber could inhibit IBU re-crystallization, but the active ingredients were released at a relatively slow rate due to the dual-resistance of fiber mat and adhesive matrix. To overcome this shortcoming, Drug-in-adhesive/fiber was designed by coupling medicated hydrophilic pressure sensitive adhesive and IBU-loaded fiber mat. This method endowed Drug-in-adhesive/fiber a fast IBU release rate and high permeated drug amount though simulative skins. This design separated enhancer from adhesive matrix, which guaranteed Drug-in-adhesive/fiber excellent adhesion forces. Hence, the plasters based on medicated fiber mats improved the compatibility among patch components.
机译：为了改善胶粘剂型贴剂不同成分之间的不良相容性，基于布洛芬（IBU）负载的纤维垫，开发了两种新型的膏药（纤维中的药物和药物中的胶粘剂/纤维）。这些纤维垫是通过在N，N-二甲基乙酰胺/丙酮的二元溶剂中对醋酸纤维素/聚乙烯吡咯烷酮复合材料进行静电纺丝制成的。身体状况研究表明，纤维中的药物可以抑制IBU的重结晶，但是由于纤维垫和粘合剂基质的双重抵抗，有效成分的释放速度相对较慢。为了克服该缺点，通过将加药的亲水性压敏胶粘剂和载有IBU的纤维垫相结合来设计胶粘剂/纤维。这种方法使药物/纤维通过模拟皮肤具有快速的IBU释放速率和高渗透药物量。这种设计将增强剂与胶粘剂基质分开，从而确保了胶粘剂/纤维的优异粘合力。因此，基于药用纤维垫的灰泥改善了贴剂组分之间的相容性。

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  • 来源
    《Journal of materials science》 |2013年第2期|333-341|共9页
  • 作者

    Yongli Shi; Shuxin Xu; Anjie Dong; Jianhua Zhang;

  • 作者单位

    School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;

    School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;

    School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;

    School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;

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