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首页> 外文期刊>Journal of materials science >A study of the diffusion characteristics of normal, delipidized and relipidized articular cartilage using magnetic resonance imaging
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A study of the diffusion characteristics of normal, delipidized and relipidized articular cartilage using magnetic resonance imaging

机译：利用磁共振成像研究正常，去脂和再脂化关节软骨的扩散特性

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摘要

This paper assesses the capacity to provide semipermeability of the synthetic layer of surface-active phospholipids created to replace the depleted surface amorphous layer of articular cartilage. The surfaces of articular cartilage specimens in normal, delipidized, and relipidized conditions following incubation in dipalmitoyl-phosphati-dylcholine and palmitoyl-oleoyl-phosphatidylcholine components of the joint lipid mixture were characterized nanoscopically with the atomic force microscope and also imaged as deuterium oxide (D_2O) diffused transiently through these surfaces in a magnetic resonance imaging enclosure. The MR images were then used to determine the apparent diffusion coefficients in a purpose-built MATLAB~(R)-based algorithm. Our results revealed that all surfaces were permeable to D_2O, but that there was a significant difference in the semipermeability of the surfaces under the different conditions, relative to the apparent diffusion coefficients. Based on the results and observations, it can be concluded that the synthetic lipid that is deposited to replace the depleted SAL of articular cartilage is capable of inducing some level of semipermeability.
机译：本文评估了能够提供合成的表面活性磷脂合成层的半透性的能力，该合成层可替代关节软骨的耗尽的表面无定形层。在关节脂质混合物的二棕榈酰磷脂酰胆碱和棕榈酰油酰磷脂酰胆碱组分中孵育后，在正常，脱脂和再脂化条件下的关节软骨标本的表面用原子力显微镜进行纳米表征，并成像为氧化氘（D_2O ）通过磁共振成像外壳中的这些表面瞬时扩散。然后，在基于MATLAB®的专用算法中，将MR图像用于确定视在扩散系数。我们的结果表明，所有表面都可渗透D_2O，但相对于表观扩散系数，在不同条件下表面的半透性存在显着差异。根据结果​​和观察结果，可以得出结论，沉积的合成脂质代替关节软骨衰竭的SAL能够诱导一定水平的半透性。

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  • 来源
    《Journal of materials science》 |2013年第4期|1005-1013|共9页
  • 作者

    K. Q. Yusuf; K. I. Momot; R. M. Wellard; A. Oloyede;

  • 作者单位

    School of Chemistry, Physical and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, GPO Box 2434, Brisbane, QLD 4001, Australia;

    School of Chemistry, Physical and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, GPO Box 2434, Brisbane, QLD 4001, Australia;

    School of Chemistry, Physical and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, GPO Box 2434, Brisbane, QLD 4001, Australia;

    School of Chemistry, Physical and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, GPO Box 2434, Brisbane, QLD 4001, Australia;

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