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首页> 外文期刊>Journal of materials science >Biomimetic apatite-based biomaterials: on the critical impact of synthesis and post-synthesis parameters
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Biomimetic apatite-based biomaterials: on the critical impact of synthesis and post-synthesis parameters

机译：仿生磷灰石基生物材料：对合成和合成后参数的关键影响

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摘要

Nanocrystalline apatites are major constituents of hard tissues, and attempts are made worldwide to prepare synthetic analogs. However the impact of synthesis/ postsynthesis parameters is often disregarded. Based on an updated knowledge on such compounds, we inspected the effects of synthesis parameters (maturation time, temperature, pH, nature of counter-ions) and post-treatments (re-immersion in aqueous media, thermal treatment) on physicochemical characteristics. Great modifications were noticed during the 3 first days of maturation, where a progressive evolution of the apatite phase (localized in the core of the nanocrystals) toward stoichiometry was observed at the expense of the non-apatitic surface layer which progressively disappears. Similar trends were also evidenced for maturation run under increasing temperatures, studied here in the range 20-100 ℃. pH impacted more specifically the chemical composition. The nature of the counter-ion in the starting phosphate salt influenced composition and nonstoichiometry, depending on its (in)ability to be incorporated in the lattice. Freeze-drying allowed to preserve a high surface reactivity, although further evolutions were noticed after re-immersion. Effects of a thermal treatment of dried samples were unveiled, suggesting a denaturation of the hydrated layer on the nanocrystals. This work underlines the necessity of a good control of synthesis/postsynthesis parameters for the production of biomimetic apatites.
机译：纳米晶磷灰石是硬组织的主要成分，全世界都在尝试制备合成类似物。然而，合成/后期合成参数的影响通常被忽略。基于对此类化合物的最新了解，我们检查了合成参数（成熟时间，温度，pH，抗衡离子的性质）和后处理（重新浸入水性介质中，热处理）对理化特性的影响。在成熟的前三天中注意到了巨大的改变，其中观察到磷灰石相（位于纳米晶体的核中）朝着化学计量的逐渐演变，但以非脂溶性表面层为代价，后者逐渐消失。在温度升高的情况下，成熟度也有相似的趋势，在20-100℃范围内进行了研究。 pH更具体地影响化学组成。起始磷酸盐中抗衡离子的性质会影响其组成和非化学计量，具体取决于其结合到晶格中的（不）能力。冷冻干燥可以保持较高的表面反应性，尽管在重新浸没后注意到进一步的发展。揭示了干燥样品热处理的效果，表明纳米晶体上水合层的变性。这项工作强调了对生产仿生磷灰石的合成/合成后参数进行良好控制的必要性。

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  • 来源
    《Journal of materials science》 |2012年第11期|2593-2606|共14页
  • 作者

    Nicolas Vandecandelaere; Christian Rey; Christophe Drouet;

  • 作者单位

    CIRIMAT Carnot Institute, UMR CNRS/INPT/UPS, University of Toulouse, Ensiacet 4 allee Emile Monso, 31030 Toulouse Cedex 4, France;

    CIRIMAT Carnot Institute, UMR CNRS/INPT/UPS, University of Toulouse, Ensiacet 4 allee Emile Monso, 31030 Toulouse Cedex 4, France;

    CIRIMAT Carnot Institute, UMR CNRS/INPT/UPS, University of Toulouse, Ensiacet 4 allee Emile Monso, 31030 Toulouse Cedex 4, France;

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