Evaluation of bone matrix and demineralized bone matrix incorporated PLGA matrices for bone repair

A. Champa Jayasuriya; Nabil A. Ebraheim

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Evaluation of bone matrix and demineralized bone matrix incorporated PLGA matrices for bone repair

机译：评估结合了PLGA基质的骨基质和软化骨基质的骨修复

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The aim of this study was to evaluate the composite matrices prepared using Poly(lactic-co-glycolic acid)- PLGA (85:15) by incorporating human bone matrix (BM) powder or demineralized bone matrix (DBM) powder with the weight ratio of polymer: BM or DBM (75:25) to apply for bone repair. Murine Bone Marrow Stromal Cell (BMSC) attachment was studied with different time points at 30 min, 1 h, 2 h, 4 h, and 6 h for BM/PLGA, DBM/ PLGA and PLGA control matrices. All types of matrices were linearly increased the BMSC attachment with the increase of time. Significantly higher number of BMSCs was attached to the both BM/PLGA and DBM/PLGA matrices after 2 h compared to the controls. If BM or DBM is incorporated into biodegradable PLGA matrices and cultured with BMSCs, those composite matrices could be potentially used for bone tissue engineering applications. In addition, particle migration and handling difficulties in DBM powder in clinical applications eliminate using a PLGA matrix. Furthermore, we have observed that DBM/ PLGA matrices were structurally stronger compared to the BM/PLGA or control PLGA matrices when they exposed to physiological environment for 72 days.

机译：这项研究的目的是通过以重量比掺入人体骨基质（BM）粉末或软化骨基质（DBM）粉末来评估使用聚乳酸-乙醇酸-PLGA（85:15）制备的复合基质聚合物：BM或DBM（75:25）进行骨修复。在BM / PLGA，DBM / PLGA和PLGA对照基质的30分钟，1小时，2小时，4小时和6小时的不同时间点研究了小鼠骨髓基质细胞（BMSC）的附着。随着时间的增加，所有类型的基质的BMSC附着均呈线性增加。与对照相比，在2 h后，BM / PLGA和DBM / PLGA基质均附着有大量的BMSC。如果将BM或DBM掺入可生物降解的PLGA基质中并用BMSC培养，则这些复合基质可能会用于骨组织工程应用。另外，在临床应用中DBM粉末中的颗粒迁移和处理困难消除了使用PLGA基质的麻烦。此外，我们观察到，当暴露于生理环境72天时，DBM / PLGA矩阵在结构上比BM / PLGA或对照PLGA矩阵强。

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《Journal of materials science》 |2009年第8期|1637-1644|共8页
作者
A. Champa Jayasuriya; Nabil A. Ebraheim;
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Department of Orthopaedics, University of Toledo, Health Science Campus, Mail Stop 1094, 3065 Arlington Avenue, Toledo, OH 43614-5807, USA;

Department of Orthopaedics, University of Toledo, Health Science Campus, Mail Stop 1094, 3065 Arlington Avenue, Toledo, OH 43614-5807, USA;

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Evaluation of bone matrix and demineralized bone matrix incorporated PLGA matrices for bone repair

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