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首页> 外文期刊>Journal of materials science >An in vitro study of electrically active hydroxyapatite-barium titanate ceramics using Saos-2 cells
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An in vitro study of electrically active hydroxyapatite-barium titanate ceramics using Saos-2 cells

机译：使用Saos-2细胞的电活性羟基磷灰石-钛酸钡陶瓷的体外研究

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摘要

Electrically active ceramics are of interest as bone graft substitute materials. This study investigated the ferroelectric properties of hydroxyapatite-barium titanate (HABT) composites and the behaviour of osteoblast-like cells seeded on their surfaces. A piezoelectric coefficient (d_(33)) of 57.8 pCN~(-1) was observed in HABT discs prepared for cell culture. The attachment, proliferation, viability, morphology and metabolic activity of cells cultured on unpoled HABT were comparable to those observed on commercially available hydroxyapatite at all time points. No indication of the cytotoxicity of HABT was detected. At one day after seeding, cell attachment was modified on both the positive and negative surfaces of poled HABT. After longer incubations, all parameters observed were comparable on poled and unpoled ceramics. The results indicate that HABT ceramics are biocompatible in the short term in vitro and that further investigation of cell responses to these materials under mechanical load and at longer incubation times is warranted.
机译：电活性陶瓷作为骨移植替代材料是令人感兴趣的。这项研究调查了羟基磷灰石-钛酸钡（HABT）复合材料的铁电性能以及其表面植入的成骨样细胞的行为。在准备用于细胞培养的HABT圆片中观察到57.8 pCN〜（-1）的压电系数（d_（33））。在所有时间点上，在无极HABT上培养的细胞的附着，增殖，活力，形态和代谢活性均与在市售羟基磷灰石上观察到的相当。没有检测到HABT的细胞毒性迹象。接种后一天，极化的HABT的正反两面都改变了细胞附着。长时间孵育后，观察到的所有参数在极化和非极化陶瓷上都是可比的。结果表明，HABT陶瓷在短期内具有体外生物相容性，因此有必要进一步研究在机械负载和较长孵育时间下细胞对这些材料的反应。

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  • 来源
    《Journal of materials science》 |2009年第8期|1697-1708|共12页
  • 作者

    Frances R. Baxter; Irene G. Turner; Christopher R. Bowen; Jonathan P. Gittings; Julian B. Chaudhuri;

  • 作者单位

    Department of Mechanical Engineering, Centre for Orthopaedic Biomechanics, University of Bath, BA2 7AY Bath, UK;

    Department of Mechanical Engineering, Centre for Orthopaedic Biomechanics, University of Bath, BA2 7AY Bath, UK;

    Department of Mechanical Engineering, Centre for Orthopaedic Biomechanics, University of Bath, BA2 7AY Bath, UK;

    Department of Mechanical Engineering, Centre for Orthopaedic Biomechanics, University of Bath, BA2 7AY Bath, UK;

    Department of Chemical Engineering, Centre for Regenerative Medicine, University of Bath, BA2 7AY Bath, UK;

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