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首页> 外文期刊>Journal of Materials Science >Kinetic study of controlled release of VPA and DPH antiepileptic drugs using biocompatible nanostructured sol–gel TiO2
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Kinetic study of controlled release of VPA and DPH antiepileptic drugs using biocompatible nanostructured sol–gel TiO2

机译：生物相容性纳米结构溶胶-凝胶TiO 2 对VPA和DPH抗癫痫药控释动力学的研究

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摘要

Sol–gel TiO2 porous matrix was used to host valproic acid (VPA) and phenytoin (DPH), which are commonly used as antiepileptic drugs. The addition of these drugs was carried out during the synthesis in the hydrolysis stage. In vitro short term kinetic studies on drug liberation showed that almost all samples followed a first order kinetics with the exception of one sample which had a linear behavior. High resolution electron microscopy revealed the existence of nanocrystalinity in all samples, however, electron diffraction patterns showed that some were predominantly amorphous while in others suggested a greater density of nanocrystals. NMR studies demonstrated that VPA was less mobile in a more crystalline TiO2 matrix than when the TiO2 is mainly amorphous. Some features of the kinetics of drug liberation are explained in terms of the competition between nanocrystallinity and drug content. The reservoirs were implanted by means of stereotactic surgery in Wistar rats in which epilepsy was previously induced following the Kindling model of epilepsy. The efficiency of the reservoirs was follow by electroencephalography (EEGs). In vivo studies revealed that a more crystalline sample was more effective in preventing further epileptic events than samples with a higher content of VPA but predominantly amorphous.
机译：Sol-gel TiO 2 多孔基质用于容纳丙戊酸（VPA）和苯妥英钠（DPH），它们通常用作抗癫痫药。这些药物的添加在水解阶段的合成过程中进行。关于药物释放的体外短期动力学研究表明，除了一个具有线性行为的样品外，几乎所有样品都遵循一级动力学。高分辨率电子显微镜揭示了所有样品中都存在纳米晶体，但是，电子衍射图谱表明某些晶体主要是非晶态的，而另一些则表明纳米晶体的密度更高。 NMR研究表明，与TiO 2 主要为非晶态时相比，VPA在结晶性更强的TiO 2 基质中的流动性较低。根据纳米结晶度和药物含量之间的竞争，解释了药物释放动力学的一些特征。通过立体定向手术将储库植入到Wistar大鼠中，其中Wistar大鼠先前根据癫痫的Kindling模型诱发了癫痫。脑电图（EEG）跟踪储层的效率。体内研究表明，与具有较高VPA含量但主要为非晶态的样品相比，结晶度更高的样品在预防进一步的癫痫事件方面更有效。

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