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首页> 外文期刊>Journal of Molecular Evolution >Phylogenetic Analysis of the Complete Genome Sequence of Encephalitozoon cuniculi Supports the Fungal Origin of Microsporidia and Reveals a High Frequency of Fast-Evolving Genes
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Phylogenetic Analysis of the Complete Genome Sequence of Encephalitozoon cuniculi Supports the Fungal Origin of Microsporidia and Reveals a High Frequency of Fast-Evolving Genes

机译：系统进化分析的完整的脑性脑病的基因组序列支持小孢子虫的真菌起源和揭示高频率的快速发展的基因。

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Microsporidia are unicellular eukaryotes living as obligate intracellular parasites. Lacking mitochondria, they were initially considered as having diverged before the endosymbiosis at the origin of mitochondria. That microsporidia were primitively amitochondriate was first questioned by the discovery of microsporidial sequences homologous to genes encoding mitochondrial proteins and then refuted by the identification of remnants of mitochondria in their cytoplasm. Various molecular phylogenies also cast doubt on the early divergence of microsporidia, these organisms forming a monophyletic group with or within the fungi. The 2001 proteins putatively encoded by the complete genome of Encephalitozoon cuniculi provided powerful data to test this hypothesis. Phylogenetic analysis of 99 proteins selected as adequate phylogenetic markers indicated that the E. cuniculi sequences having the lowest evolutionary rates preferentially clustered with fungal sequences or, more rarely, with both animal and fungal sequences. Because sequences with low evolutionary rates are less sensitive to the long-branch attraction artifact, we concluded that microsporidia are evolutionarily related to fungi. This analysis also allowed comparing the accuracy of several phylogenetic algorithms for a fast-evolving lineage with real rather than simulated sequences.
机译：微孢子虫是单细胞的真核生物，生活为专性的细胞内寄生虫。缺乏线粒体，最初被认为在线粒体起源于共生之前已经发散。该微孢子虫最初是线粒体，首先是通过发现与编码线粒体蛋白的基因同源的微孢子序列来质疑的，然后通过鉴定其细胞质中线粒体的残留物来反驳。各种分子系统发育也对小孢子虫的早期发散产生了怀疑，这些生物与真菌一起或在真菌内形成了单系群。推测由Encephalitozoon cuniculi的完整基因组编码的2001年蛋白质提供了强有力的数据来检验这一假设。对被选作适当系统发育标记的99种蛋白质进行的系统进化分析表明，具有最低进化速率的中华绒螯蟹序列优先与真菌序列聚簇，或者很少与动物和真菌序列聚簇。由于具有低进化速率的序列对长分支吸引伪影不太敏感，因此我们得出结论，小孢子虫在进化上与真菌有关。该分析还允许比较具有真实序列而不是模拟序列的快速进化谱系的几种系统进化算法的准确性。

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