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首页> 外文期刊>Journal of Molecular Histology >p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance
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p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance

机译：p63和p73在肝外胆管癌中的表达及其临床意义

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摘要

p53 plays a pivotal role in the prevention of human tumor formation. p73 and p63 are new members of the p53 tumor suppressor family, which are becoming increasingly recognized as important players in human tumorigenesis. However, the roles of these proteins are not well elucidated in extrahepatic bile duct (EBD) carcinoma. We examined expressions of the p63 and p73 genes and proteins in normal biliary epithelia, biliary dysplasias, and EBD carcinomas using immunohistochemistry and RT-PCR analysis. p63 and p73 proteins were overexpressed in 26.3 and 41.0% of EBD carcinomas, respectively. p63 protein expression was more frequent in tumors with vascular invasion (P = 0.002) and distal location (P = 0.04), while p73 expression was more common in cancers with deeper tumor invasion (P = 0.04). Patients with tumors co-expressing both p63 and p73 were found to have a significantly worse overall survival rate compared to those with either p63 or p73 expression (P < 0.05) as determined in univariate and multivariate analyses. Our results strongly imply that the p53 family members have different functions in EBD carcinomas. Our data also indicate that interactions between p63 and p73 play an important role in tumorigenesis of EBD carcinoma.
机译：p53在预防人类肿瘤形成中起关键作用。 p73和p63是p53肿瘤抑制家族的新成员，它们被越来越多地认为是人类肿瘤发生中的重要角色。但是，这些蛋白在肝外胆管癌中的作用尚不清楚。我们使用免疫组织化学和RT-PCR分析检查了正常胆道上皮细胞，胆道异型增生和EBD癌中p63和p73基因和蛋白的表达。 p63和p73蛋白分别在26.3％和41.0％的EBD癌中过表达。 p63蛋白表达在具有血管侵犯（P = 0.002）和远端定位（P = 0.04）的肿瘤中更为频繁，而p73表达在肿瘤侵犯较深的癌症中更为常见（P = 0.04）。单因素和多因素分析显示，与同时表达p63或p73的患者相比，同时表达p63和p73的患者的总生存率明显差（P <0.05）。我们的结果强烈暗示p5​​3家族成员在EBD癌中具有不同的功能。我们的数据还表明，p63和p73之间的相互作用在EBD癌的肿瘤发生中起重要作用。

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