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Expression of Bcl-2 and Bax protein in normal pineal gland in children and young adult

机译：Bcl-2和Bax蛋白在儿童和青少年正常松果体中的表达

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摘要

The Bcl family contains both pro and antiapoptotic proteins participating in the regulation of neuronal cell death in several pathological conditions. However, very little is known about physiological profiles of Bcl-2/Bax expression in normal brain. In this study, we examined expression profile of Bcl-2 and Bax proteins in normal pineal gland in children. The material for analysis was obtained by biopsy of pineal parenchyma during surgery of pineal cysts. All specimens were labeled immunohistochemically and analyzed by means of confocal laser scanning microscope. We found only few Bcl-2 expressing (0.7%) and no Bax-immunopositive (0.0%) pinealocytes. Bcl-2-positive cells were mature neurons, neither young ones nor glia.
机译：Bcl家族包含在几种病理条件下参与调节神经元细胞死亡的前蛋白和抗凋亡蛋白。但是，关于正常大脑中Bcl-2 / Bax表达的生理特征知之甚少。在这项研究中，我们检查了儿童正常松果体中Bcl-2和Bax蛋白的表达谱。用于分析的材料是通过在松果体囊肿手术期间对松果体实质进行活检而获得的。所有标本都进行了免疫组织化学标记，并通过共聚焦激光扫描显微镜进行了分析。我们发现只有少数Bcl-2表达（0.7％），而没有Bax免疫阳性（0.0％）松果细胞。 Bcl-2阳性细胞是成熟的神经元，既不是年轻人也不是神经胶质。

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  • 来源
    《Journal of Molecular Histology》 |2006年第2期|5-7|共3页
  • 作者

    Wiesław Marcol; Katarzyna Kotulska; Magdalena Larysz-Brysz; Izabela Malinowska-Kołodziej; Marek Mandera; Joanna Lewin-Kowalik;

  • 作者单位

    Department of Physiology Medical University of Silesia 18 Medyków 40-752 Katowice Poland;

    Department of Physiology Medical University of Silesia 18 Medyków 40-752 Katowice Poland;

    Department of Physiology Medical University of Silesia 18 Medyków 40-752 Katowice Poland;

    Department of Physiology Medical University of Silesia 18 Medyków 40-752 Katowice Poland;

    Division of Pediatric Neurosurgery Department of Pediatric Surgery Medical University of Silesia Katowice Poland;

    Department of Physiology Medical University of Silesia 18 Medyków 40-752 Katowice Poland;

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