• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of nano research >Production of Ibuprofen-Loaded Solid Lipid Nanoparticles Using Rapid Expansion of Supercritical Solution
【24h】

Production of Ibuprofen-Loaded Solid Lipid Nanoparticles Using Rapid Expansion of Supercritical Solution

机译：使用超临界溶液的快速膨胀制备布洛芬负载的固体脂质纳米颗粒

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this study was to prepare ibuprofen loaded solid lipid nanoparticles (IBU-SLNs) that is, effective in oral drug delivery. IBU-SLNs were synthesized by co-precipitation of rapid expansion of supercritical solution (CO-RESS). The produced SLNs consisted of stearic acid as lipid matrix. The unprocessed stearic acid, ibuprofen and IBU-SLNs were characterized by means of scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), fourier transform infrared spectrophotometry (FTIR) and high performance liquid chromatography (HPLC). XRD patterns along with DSC showed that ibuprofen was present in both amorphous and crystalline form within lipid matrix. FTIR showed that molecular interactions that could alter the chemical structure of the IBU did not occur. The RESS process could produce ultrafine spherical particles of SLNs with high drug loading capacity. The IBU dissolution profile showed that the formulated SLNs have effectively increased the IBU solubility.
机译：这项研究的目的是制备对布洛芬有效的固体脂质纳米粒（IBU-SLNs），可有效口服药物。 IBU-SLN是通过快速沉淀超临界溶液（CO-RESS）的共沉淀而合成的。产生的SLN由硬脂酸作为脂质基质组成。通过扫描电子显微镜（SEM），X射线衍射（XRD），差示扫描量热法（DSC），傅立叶变换红外分光光度法（FTIR）和高效液相色谱（ HPLC）。 XRD图谱与DSC一起显示，布洛芬在脂质基质中以无定形和结晶形式存在。 FTIR显示未发生可能改变IBU化学结构的分子相互作用。 RESS工艺可以生产具有高载药量的超细球形SLN球形颗粒。 IBU溶出度曲线表明，配制的SLNs有效增加了IBU溶度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号